Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Nusinersen [USAN:INN]
RN: 1258984-36-9
UNII: 5Z9SP3X666
InChIKey: WWFDJIVIDXJAQR-FFWSQMGZSA-N

Note

  • An antisense oligonucleotide that induces SMN protein expression.

Classification Code

  • Treatment of Spinal Muscular Atrophy

Molecular Weight

  • 7127.239
 
* denotes mobile formatted website

Links to Resources


Search for this InChIKey on the Web

Names and Synonyms

Name of Substance

  • Nusinersen
  • Nusinersen [USAN:INN]

Synonyms

  • ASO-10-27
  • ISIS 396443
  • ISIS SMNRx
  • ISIS-SMN(Rx)
  • ISIS-SMNRx
  • Nusinersen
  • RNA, (2'-0-(2-methoxyethyi))(p-thio)(m5u-c-a-c-m5u-m5u-m5u-c-a-m5ua- a-m5 u-g-c-m5u-g-g)
  • Spinraza
  • UNII-5Z9SP3X666

Registry Numbers

CAS Registry Number

  • 1258984-36-9

FDA UNII

  • 5Z9SP3X666

System Generated Number

  • 1258984369

Structure Descriptors

InChI

1S/C234H340N61O128P17S17/c1-106-66-278(224(308)261-178(106)235)205-162(356-50-32-338-14)144(119(391-205)79-373-425(320,442)407-143-117(77-296)389-204(161(143)355-49-31-337-13)282-70-110(5)193(298)271-228(282)312)410-431(326,448)383-89-129-154(172(366-60-42-348-24)215(401-129)289-99-254-135-182(239)246-95-250-186(135)289)419-436(331,453)379-81-121-145(163(357-51-33-339-15)206(393-121)279-67-107(2)179(236)262-225(279)309)408-426(321,443)375-83-123-149(167(361-55-37-343-19)210(395-123)284-72-112(7)195(300)273-230(284)314)413-429(324,446)378-86-125-150(168(362-56-38-344-20)211(397-125)285-73-113(8)196(301)274-231(285)315)414-430(325,447)377-85-124-148(166(360-54-36-342-18)209(396-124)283-71-111(6)194(299)272-229(283)313)412-428(323,445)374-80-120-147(165(359-53-35-341-17)208(392-120)281-69-109(4)181(238)264-227(281)311)411-432(327,449)384-90-130-155(173(367-61-43-349-25)216(402-130)290-100-255-136-183(240)247-96-251-187(136)290)420-437(332,454)381-87-127-152(170(364-58-40-346-22)213(399-127)287-75-115(10)198(303)276-233(287)317)415-433(328,450)385-91-131-157(175(369-63-45-351-27)218(403-131)292-102-257-138-185(242)249-98-253-189(138)292)422-440(335,457)386-92-132-156(174(368-62-44-350-26)217(404-132)291-101-256-137-184(241)248-97-252-188(137)291)421-438(333,455)382-88-128-153(171(365-59-41-347-23)214(400-128)288-76-116(11)199(304)277-234(288)318)417-435(330,452)388-94-134-159(177(371-65-47-353-29)220(406-134)295-105-260-141-192(295)267-223(245)270-202(141)307)423-439(334,456)380-82-122-146(164(358-52-34-340-16)207(394-122)280-68-108(3)180(237)263-226(280)310)409-427(322,444)376-84-126-151(169(363-57-39-345-21)212(398-126)286-74-114(9)197(302)275-232(286)316)416-434(329,451)387-93-133-158(176(370-64-46-352-28)219(405-133)294-104-259-140-191(294)266-222(244)269-201(140)306)418-424(319,441)372-78-118-142(297)160(354-48-30-336-12)203(390-118)293-103-258-139-190(293)265-221(243)268-200(139)305/h66-76,95-105,117-134,142-177,203-220,296-297H,30-65,77-94H2,1-29H3,(H,319,441)(H,320,442)(H,321,443)(H,322,444)(H,323,445)(H,324,446)(H,325,447)(H,326,448)(H,327,449)(H,328,450)(H,329,451)(H,330,452)(H,331,453)(H,332,454)(H,333,455)(H,334,456)(H,335,457)(H2,235,261,308)(H2,236,262,309)(H2,237,263,310)(H2,238,264,311)(H2,239,246,250)(H2,240,247,251)(H2,241,248,252)(H2,242,249,253)(H,271,298,312)(H,272,299,313)(H,273,300,314)(H,274,301,315)(H,275,302,316)(H,276,303,317)(H,277,304,318)(H3,243,265,268,305)(H3,244,266,269,306)(H3,245,267,270,307)/t117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,142-,143-,144-,145-,146-,147-,148-,149-,150-,151-,152-,153-,154-,155-,156-,157-,158-,159-,160-,161-,162-,163-,164-,165-,166-,167-,168-,169-,170-,171-,172-,173-,174-,175-,176-,177-,203-,204-,205-,206-,207-,208-,209-,210-,211-,212-,213-,214-,215-,216-,217-,218-,219-,220-,424?,425?,426?,427?,428?,429?,430?,431?,432?,433?,434?,435?,436?,437?,438?,439?,440?/m1/s1

InChIKey

WWFDJIVIDXJAQR-FFWSQMGZSA-N

Smiles

COCCO[C@@H]1[C@H](O)[C@@H](COP(=S)(O)O[C@@H]2[C@@H](COP(=O)(S)O[C@@H]3[C@@H](COP(=S)(O)O[C@@H]4[C@@H](COP(=S)(O)O[C@@H]5[C@@H](COP(=S)(O)O[C@@H]6[C@@H](COP(=S)(O)O[C@@H]7[C@@H](COP(=S)(O)O[C@@H]8[C@@H](COP(=S)(O)O[C@@H]9[C@@H](COP(=S)(O)O[C@@H]%10[C@@H](COP(=S)(O)O[C@@H]%11[C@@H](COP(=S)(O)O[C@@H]%12[C@@H](COP(=S)(O)O[C@@H]%13[C@@H](COP(=S)(O)O[C@@H]%14[C@@H](COP(=S)(O)O[C@@H]%15[C@@H](COP(=S)(O)O[C@@H]%16[C@@H](COP(=S)(O)O[C@@H]%17[C@@H](COP(=S)(O)O[C@@H]%18[C@@H](CO)O[C@H]([C@@H]%18OCCOC)N%19C=C(C)C(=O)NC%19=O)O[C@H]([C@@H]%17OCCOC)N%20C=C(C)C(=NC%20=O)N)O[C@H]([C@@H]%16OCCOC)n%21cnc%22c(N)ncnc%21%22)O[C@H]([C@@H]%15OCCOC)N%23C=C(C)C(=NC%23=O)N)O[C@H]([C@@H]%14OCCOC)N%24C=C(C)C(=O)NC%24=O)O[C@H]([C@@H]%13OCCOC)N%25C=C(C)C(=O)NC%25=O)O[C@H]([C@@H]%12OCCOC)N%26C=C(C)C(=O)NC%26=O)O[C@H]([C@@H]%11OCCOC)N%27C=C(C)C(=NC%27=O)N)O[C@H]([C@@H]%10OCCOC)n%28cnc%29c(N)ncnc%28%29)O[C@H]([C@@H]9OCCOC)N%30C=C(C)C(=O)NC%30=O)O[C@H]([C@@H]8OCCOC)n%31cnc%32c(N)ncnc%31%32)O[C@H]([C@@H]7OCCOC)n%33cnc%34c(N)ncnc%33%34)O[C@H]([C@@H]6OCCOC)N%35C=C(C)C(=O)NC%35=O)O[C@H]([C@@H]5OCCOC)n%36cnc%37C(=O)NC(=Nc%36%37)N)O[C@H]([C@@H]4OCCOC)N%38C=C(C)C(=NC%38=O)N)O[C@H]([C@@H]3OCCOC)N%39C=C(C)C(=O)NC%39=O)O[C@H]([C@@H]2OCCOC)n%40cnc%41C(=O)NC(=Nc%40%41)N)O[C@H]1n%42cnc%43C(=O)NC(=Nc%42%43)N