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Substance Name: Oxethazaine [USAN:JAN]
RN: 126-27-2
UNII: IP8QT76V17
InChIKey: FTLDJPRFCGDUFH-UHFFFAOYSA-N

Note

  • Surface anesthetic used mainly orally in chronic gastritis & heartburn to analgize the gastric mucosa.

Molecular Formula

  • C28-H41-N3-O3

Molecular Weight

  • 467.6499
 

Classification Codes

  • Anesthetic (Topical)
  • Anesthetics
  • Anesthetics, Local
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Mutation Data
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Oxetacaine [INN]
  • Oxethazaine
  • Oxethazaine [USAN:JAN]

Synonyms

  • 2,2'-((2-Hydroxyethyl)imino)bis(N-(1,1-dimethyl-2-phenylethyl)-N-methylacetamide)
  • 2,2'-((2-Hydroxyethyl)imino)bis(N-(alpha,alpha-dimethylphenethyl)-N-methylacetamide)
  • 2-Di(N-methyl-N-phenyl-tert-butyl-carbamoylmethyl)aminoethanol
  • 4-12-00-02822 (Beilstein Handbook Reference)
  • Acetamide, 2,2'-((2-hydroxyethyl)imino)bis(N-(1,1-dimethyl-2-phenylethyl)-N-methyl-
  • BRN 2404063
  • CCRIS 4692
  • EINECS 204-780-5
  • Emoren
  • FH 099
  • Milzine
  • Mucaine
  • Mucoxin
  • Muthesa
  • N,N-Bis(N-methyl-N-phenyl-tert-butylacetamido)-beta-hydroxyethylamine
  • Oxaethacainum
  • Oxaine
  • Oxetacaina
  • Oxetacaina [INN-Spanish]
  • Oxetacaine
  • Oxetacainum
  • Oxetacainum [INN-Latin]
  • Oxethacaina
  • Oxethacaina [Italian]
  • Oxethacaine
  • Oxethazaine
  • Stomacain
  • Topicain
  • UNII-IP8QT76V17
  • WY 806
  • Wy-806

Systematic Names

  • Acetamide, 2,2'-((2-hydroxyethyl)imino)bis(N-(1,1-dimethyl-2-phenylethyl)-N-methyl-
  • Acetamide, 2,2'-((2-hydroxyethyl)imino)bis(N-(alpha,alpha-dimethylphenethyl)-N-methyl-
  • Oxetacaine
  • Oxethazaine

Mixture Names

  • Betalgil
  • Mucaine
  • Muthesa
  • Tepilta

Registry Numbers

CAS Registry Number

  • 126-27-2

FDA UNII

  • IP8QT76V17

Related Registry Number

  • 13930-31-9 (hydrochloride)

System Generated Number

  • 0000126272

Structure Descriptors

InChI

1S/C28H41N3O3/c1-27(2,19-23-13-9-7-10-14-23)29(5)25(33)21-31(17-18-32)22-26(34)30(6)28(3,4)20-24-15-11-8-12-16-24/h7-16,32H,17-22H2,1-6H3

InChIKey

FTLDJPRFCGDUFH-UHFFFAOYSA-N

Smiles

C(N(C(CN(CC(N(C(Cc1ccccc1)(C)C)C)=O)CCO)=O)C)(Cc1ccccc1)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 27mg/kg (27mg/kg)   Gazzetta Medica Italiana. Vol. 134, Pg. 642, 1975.
mouse LD50 oral 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 283, 1995.
mouse LD50 subcutaneous 58mg/kg (58mg/kg)   Gazzetta Medica Italiana. Vol. 134, Pg. 642, 1975.
rat LD50 intraperitoneal 30mg/kg (30mg/kg)   Gazzetta Medica Italiana. Vol. 134, Pg. 642, 1975.
rat LD50 oral 1gm/kg (1000mg/kg)   Drugs in Japan Vol. -, Pg. 283, 1995.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 104 deg C   EXP
log P (octanol-water) 3.370 (none)   EST
Atmospheric OH Rate Constant 1.38E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.