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Substance Name: Chloroprene
RN: 126-99-8
UNII: 42L93DWV3A
InChIKey: YACLQRRMGMJLJV-UHFFFAOYSA-N
Note
- Toxic, possibly carcinogenic, monomer of neoprene, a synthetic rubber; causes damage to skin, lungs, CNS, kidneys, liver, blood cells and fetuses. Synonym: 2-chlorobutadiene.
Molecular Formula
- C4-H5-Cl
Molecular Weight
- 88.5365
- All
- Classifications
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- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Mutation Data
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
Superlist Classification Codes
- Overall Carcinogenic Evaluation: Group 2B
- Reasonlly Anticipated as a Human Carcinogen
- TWA (10 ppm); skin
- TWA 25 ppm (90 mg/m3); skin
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Names and Synonyms
Results Name
- Chloroprene
Name of Substance
- 2-Chloro-1,3-butadiene
- Chloroprene
MeSH Heading
- Chloroprene
Synonyms
- 1,3-Butadiene, 2-chloro-
- 2-Chloor-1,3-butadieen
- 2-Chloor-1,3-butadieen [Dutch]
- 2-Chlor-1,3-butadien
- 2-Chlor-1,3-butadien [German]
- 2-Chlorobuta-1,3-diene
- 2-Chlorobutadiene
- 2-Cloro-1,3-butadiene
- 2-Cloro-1,3-butadiene [Italian]
- CCRIS 873
- Chlorobutadiene
- Chloropreen
- Chloropreen [Dutch]
- Chloropren
- Chloropren [German, Polish]
- Chloroprene
- Cloroprene
- Cloroprene [Italian]
- EC 204-818-0
- EINECS 204-818-0
- HSDB 1618
- Neoprene
- NSC 18589
- UNII-42L93DWV3A
Systematic Names
- 1,3-Butadiene, 2-chloro-
- 2-Chlorobuta-1,3-diene
- Chloroprene
Superlist Names
- 1,3-Butadiene, 2-chloro-
- 2-Chloro-1,3-butadiene
- beta-Chloroprene
- beta-Chloroprene 2-Chloro-1,3-butadiene
- Chloroprene
- Chloroprene, inhibited
- Chloroprene, inhibited [UN1991] [Flammable liquid, Poison]
- Chloroprene, uninhibited
- Chloroprene, uninhibited [Forbidden]
- UN1991
Registry Numbers
CAS Registry Number
- 126-99-8
FDA UNII
- 42L93DWV3A
Other Registry Number
- 184963-09-5
System Generated Number
- 0000126998
Structure Descriptors
InChI
InChI=1S/C4H5Cl/c1-3-4(2)5/h3H,1-2H2InChIKey
YACLQRRMGMJLJV-UHFFFAOYSA-NSmiles
ClC(=C)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
cat | LCLo | inhalation | 1290mg/m3/8H (1290mg/m3) | Journal of Industrial Hygiene and Toxicology. Vol. 18, Pg. 240, 1936. | |
cat | LDLo | subcutaneous | 100mg/kg (100mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 18, Pg. 240, 1936. | |
mouse | LC50 | inhalation | 2300mg/m3 (2300mg/m3) | Zhurnal Eksperimental'noi i Klinicheskoi Meditsiny. Journal of Experimental and Clinical Medicine. Vol. (6), Pg. 66, 1969. | |
mouse | LD50 | oral | 146mg/kg (146mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 38, 1982. | |
mouse | LDLo | subcutaneous | 1gm/kg (1000mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD | Journal of Industrial Hygiene and Toxicology. Vol. 18, Pg. 240, 1936. |
pigeon | LDLo | subcutaneous | 13gm/kg (13000mg/kg) | Journal of Industrial Hygiene and Toxicology. Vol. 18, Pg. 240, 1936. | |
rabbit | LCLo | inhalation | 3870mg/m3/8H (3870mg/m3) | Journal of Industrial Hygiene and Toxicology. Vol. 18, Pg. 240, 1936. | |
rabbit | LDLo | intravenous | 96mg/kg (96mg/kg) | SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" BLOOD: OTHER CHANGES | Sbornik Lekarsky. Collection of Medical Works. Vol. 44, Pg. 63, 1942. |
rat | LC50 | inhalation | 11800mg/m3/4H (11800mg/m3) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 38, 1982. | |
rat | LD50 | oral | 450mg/kg (450mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 38, 1982. | |
rat | LDLo | subcutaneous | 500mg/kg (500mg/kg) | BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: CYANOSIS | Journal of Industrial Hygiene and Toxicology. Vol. 18, Pg. 240, 1936. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | -1.30E+02 | deg C | EXP | |
Boiling Point | 59.4 | deg C | EXP | |
log P (octanol-water) | 2.530 | (none) | EST | |
Water Solubility | 875 | mg/L | 25 | EST |
Vapor Pressure | 216 | mm Hg | 25 | EXP |
Henry's Law Constant | 0.056 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.21E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.