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Substance Name: Lobucavir
RN: 126062-18-8
InChIKey: GWFOVSGRNGAGDL-FSDSQADBSA-N

Note

  • Inhibits the replication of HIV virus in T cells, monocytes & macrophages in vitro by inhibiting DNA polymerase and viral DNA synthesis.

Molecular Formula

  • C11-H15-N5-O3

Molecular Weight

  • 265.272
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral Agents
  • Enzyme Inhibitors
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Names and Synonyms

Name of Substance

  • Lobucavir

Synonyms

  • (+-)-Cyclobut-G
  • (+-)-Lobucavir
  • 2-Amino-9-(2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro-6H-purin-6-one
  • 9-(2,3-Bis-(hydroxymethyl)-1-cyclobutyl)guanine
  • BMS 180194
  • C-Oxt-G
  • Carbocyclic oxetanocin G
  • Cyclobut-G
  • SQ 33054

Systematic Names

  • 6H-Purin-6-one, 2-amino-9-((1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro-, rel-
  • 6H-Purin-6-one, 2-amino-9-(2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro-, (1alpha,2beta,3alpha)-(+-)-

Registry Numbers

CAS Registry Number

  • 126062-18-8

Other Registry Number

  • 126373-87-3

System Generated Number

  • 0126062188

Structure Descriptors

InChI

1S/C11H15N5O3/c12-11-14-9-8(10(19)15-11)13-4-16(9)7-1-5(2-17)6(7)3-18/h4-7,17-18H,1-3H2,(H3,12,14,15,19)/t5-,6-,7-/m1/s1

InChIKey

GWFOVSGRNGAGDL-FSDSQADBSA-N

Smiles

n1c(N)[nH]c2n([C@H]3[C@@H]([C@H](C3)CO)CO)cnc2c1=O