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Substance Name: Taxine
RN: 12607-93-1
UNII: 1JY8F757VJ
InChIKey: KOTXAHKUCAQPQA-AAUVPWARSA-N

Note

  • Mixture of alkaloids isolated from Taxus baccata.

Classification Codes

  • Drug / Therapeutic Agent
  • Natural Product

Molecular Formula

  • C37-H51-N-O10

Molecular Weight

  • 641.753
 
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Names and Synonyms

Name of Substance

  • Taxine

Synonyms

  • EINECS 235-716-4
  • HSDB 3541
  • Taxin
  • Taxin [German]
  • Taxine
  • UNII-1JY8F757VJ

Systematic Name

  • Taxine

Registry Numbers

CAS Registry Number

  • 12607-93-1

FDA UNII

  • 1JY8F757VJ

System Generated Number

  • 0012607931

Structure Descriptors

InChI

1S/C35H47NO10/c1-18-24(44-19(2)37)15-23-26(45-20(3)38)14-22-17-35(6,32(42)30(40)28(18)34(23,4)5)27(39)16-25(22)46-33(43)31(41)29(36(7)8)21-12-10-9-11-13-21/h9-14,23-27,29-31,39-41H,15-17H2,1-8H3/b22-14+/t23?,24-,25-,26-,27-,29-,30+,31+,35-/m0/s1

InChIKey

KOTXAHKUCAQPQA-AAUVPWARSA-N

Smiles

C=12[C@H](C[C@H](O)[C@@](C2)(C([C@H](O)C=2C([C@@H]([C@H](C1)OC(C)=O)C[C@@H](OC(C)=O)C2C)(C)C)=O)C)OC([C@@H]([C@H](c1ccccc1)N(C)C)O)=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo intraperitoneal 25mg/kg (25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 205, 1932.
dog LDLo intraperitoneal 9mg/kg (9mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 205, 1932.
frog LDLo parenteral 17mg/kg (17mg/kg) BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 205, 1932.
guinea pig LDLo intraperitoneal 14mg/kg (14mg/kg) BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP		 Zeitschrift fuer die Gesamte Experimentelle Medizin. Vol. 29, Pg. 310, 1922.
guinea pig LDLo subcutaneous 10mg/kg (10mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 205, 1932.
mouse LDLo intraperitoneal 11mg/kg (11mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 205, 1932.
rabbit LDLo intraperitoneal 6mg/kg (6mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: ATAXIA		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 205, 1932.
rabbit LDLo intravenous 3mg/kg (3mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD		 Quarterly Journal of Pharmacy & Pharmacology. Vol. 5, Pg. 205, 1932.
rabbit LDLo oral 22mg/kg (22mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)		 Zeitschrift fuer die Gesamte Experimentelle Medizin. Vol. 29, Pg. 310, 1922.