Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Technetium Tc 99m Tilmanocept [USAN]
RN: 1262984-82-6
UNII: 8IHI69PQTC

Note

  • NCI: 99mTc-DTPA-mannosyl-dextran A radiolabeled macromolecule consisting of the chelating agent diethylenetriamine pentaacetic acid (DTPA) and mannose each attached to a dextran backbone and labeled with metastable technetiumTc-99 (Tc-99m), with mannose binding and radioisotopic activities. Upon injection, the mannose moiety of 99mTc-DTPA-mannosyl-dextran binds to mannose-binding protein (MBP). As MBPs reside on the surface of dendritic cells and macrophages, this gamma-emitting macromolecule tends to accumulate in lymphatic tissue where it may be imaged using gamma scintigraphy. This agent exhibits rapid clearance from the injection site, rapid uptake and high retention within the first draining lymph node, and low uptake by the remaining lymph nodes. MBP is a C-type lectin that binds mannose or fucose carbohydrate residues, such as those found on the surfaces of many pathiogens, and once bound activates the complement system. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Formula

  • (C6-H10-O5)n(C19-H28-N4-O9-S-99mTc)b.(C13-H24-N2-O5-S2)c.(5H11NS)a

Molecular Weight

  • 452.1606
 

Classification Code

  • Diagnostic Radiopharmaceutical

Names and Synonyms

Name of Substance

  • Technetium Tc 99m Tilmanocept [USAN]

Synonyms

  • 1600
  • 99mTc-tilmanocept
  • Lymphoseek Kit
  • Tc 99m tilmanocept
  • Tc-DTPA-mannosyl-dextran
  • Technetium Tc 99m tilmanocept
  • Tilmanocept
  • UNII-8IHI69PQTC

Systematic Names

  • (1->6)-alpha-D-pyranoglucan partially etherified by 3-((2-aminoethyl)sulfanyl)propyl, 17- carboxy-10,13,16-tris(carboxymethyl)-8-oxo-4-thia-7,10,13,16-tetraazaheptadecyl and 3-((2-{(2-(L-mannopyranosylsulfanyl)acetimidoyl)amino}ethyl)sulfanyl)propyl, (99mTc)Technetium coordination compound
  • Technetium-99Tc, dextran 3-((2-aminoethyl)thio)propyl 17-carboxy-10,13,16-tris(carboxymethyl)-8-oxo-4-thia-7,10,13,16-tetraazaheptadec-1-yl 3-((2-((1-imino-2-(D-mannopyranosylthio)ethyl)amino)ethyl)thio)propyl ether complexes

Registry Numbers

CAS Registry Number

  • 1262984-82-6

FDA UNII

  • 8IHI69PQTC

System Generated Number

  • 1262984826