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Substance Name: Perforin
RN: 126465-35-8


  • A calcium-dependent pore-forming protein synthesized in cytolytic LYMPHOCYTES and sequestered in secretory granules. Upon immunological reaction between a cytolytic lymphocyte and a target cell, perforin is released at the plasma membrane and polymerizes into transmembrane tubules (forming pores) which lead to death of a target cell.

Classification Codes

  • Cytotoxins
  • Noxae
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Links to Resources

Names and Synonyms

Name of Substance

  • Perforin

MeSH Heading

  • Perforin


  • Cytolysin, rat
  • Perforin
  • Perforin 1
  • Perforin 2
  • Pore-forming protein, perforin
  • Rat cytolysin

Systematic Name

  • Perforin (rat clone RC2-1 protein moiety reduced)

Registry Numbers

CAS Registry Number

  • 126465-35-8

System Generated Number

  • 0126465358