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Substance Name: Mupirocin [USAN:USP:INN:BAN]
RN: 12650-69-0
UNII: D0GX863OA5
InChIKey: MINDHVHHQZYEEK-HBBNESRFSA-N
Note
- A topically used antibiotic from a strain of Pseudomonas fluorescens. It has shown excellent activity against gram-positive staphylococci and streptococci. The antibiotic is used primarily for the treatment of primary and secondary skin disorders, nasal infections, and wound healing.
Molecular Formula
- C26-H44-O9
Molecular Weight
- 500.6246
Classification Codes
- Anti-Bacterial Agents
- Anti-Infective Agents
- Antibacterial (Topical)
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Natural Product
- Protein Synthesis Inhibitors
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Names and Synonyms
Name of Substance
- Mupirocin
- Mupirocin [USAN:USP:INN:BAN]
MeSH Heading
- Mupirocin
Synonyms
- (E)-(2S,3R,4R,5S)-5-((2S,3S,4S,5S)-2,3-Epoxy-5-hydroxy-4-methylhexyl)tetrahydro-3,4-dihydroxy-beta-methyl-2H-pyran-2-crotonic acid, ester with 9-hydroxynonanoic acid
- 8-Carboxyoctyl (E)-4-(2S,3R,4R,5S)-5-((2S,3S,4S,5S)-2,3-epoxy-5-hydroxy-4-methylhexyl)-3,4-dihydroxytetrahydro-2H-pyran-2-yl)-3-methylcrotonat
- Bactoderm
- Bactroban
- Bactroban Ointment
- BRL 4910A
- Centany
- Mupirocin
- Mupirocin Neo-Sensitabs
- Mupirocina
- Mupirocina [Spanish]
- Mupirocine
- Mupirocine [French]
- Mupirocinum
- Mupirocinum [Latin]
- Nonanoic acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2H-pyran-2-yl)-2-butenyl)oxy)-, (2S-(2alpha(E),3beta,4beta,5alpha(2R*,3R*(1R*,2R*))))-
- Plasimine
- Pseudomonic acid
- Pseudomonic acid A
- trans-Pseudomonic acid
- Turixin
- UNII-D0GX863OA5
Systematic Name
- Nonanoic acid, 9-((3-methyl-1-oxo-4-(tetrahydro-3,4-dihydroxy-5-((3-(2-hydroxy-1-methylpropyl)oxiranyl)methyl)-2H-pyran-2-yl)-2-butenyl)oxy)-, (2S-(2alpha(E),3beta,4beta,5alpha(2R*,3R*(1R*,2R*))))-
Registry Numbers
CAS Registry Number
- 12650-69-0
FDA UNII
- D0GX863OA5
Other Registry Number
- 62916-63-6
System Generated Number
- 0012650690
Structure Descriptors
InChI
InChI=1S/C26H44O9/c1-16(13-23(30)33-11-9-7-5-4-6-8-10-22(28)29)12-20-25(32)24(31)19(15-34-20)14-21-26(35-21)17(2)18(3)27/h13,17-21,24-27,31-32H,4-12,14-15H2,1-3H3,(H,28,29)/b16-13+/t17-,18-,19-,20-,21-,24+,25-,26-/m0/s1InChIKey
MINDHVHHQZYEEK-HBBNESRFSA-NSmiles
C[C@H](O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 1638mg/kg (1638mg/kg) | United States Patent Document. Vol. #4206224, | |
mouse | LD50 | oral | 5gm/kg (5000mg/kg) | United States Patent Document. Vol. #4206224, | |
mouse | LD50 | subcutaneous | 4gm/kg (4000mg/kg) | United States Patent Document. Vol. #4206224, | |
rat | LD50 | intravenous | 1310mg/kg (1310mg/kg) | United States Patent Document. Vol. #4206224, | |
rat | LD50 | oral | 5gm/kg (5000mg/kg) | United States Patent Document. Vol. #4206224, | |
rat | LD50 | subcutaneous | 5gm/kg (5000mg/kg) | United States Patent Document. Vol. #4206224, |