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Substance Name: Sibiromycin
RN: 12684-33-2
InChIKey: RAGFPHFDFVNLCG-INYQBOQCSA-N

Note

  • Aminoglycoside antibiotic isolated from Streptosporangium sibiricum has antineoplastic properties & inhibits growth of Bacillus mycoides, Bacillus subtilis, Staphylococcus aureus & Escherichia coli.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formula

  • C24-H31-N3-O7

Molecular Weight

  • 475.5387
 
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Names and Synonyms

Name of Substance

  • Sibiromycin

Synonyms

  • Sibiromycin
  • Sybiromycin

Systematic Name

  • 5H-Pyrrolo(2,1-c)(1,4)benzodiazepin-5-one, 7-((4,6-dideoxy-3-C-methyl-4-(methylamino)-alpha-L-mannopyranosyl)oxy)-1,10,11,11a-treahydro-9,11-dihydroxy-8-methyl-2-(1E)-1-propenyl-, (11R,11aS)-

Registry Numbers

CAS Registry Number

  • 12684-33-2

System Generated Number

  • 0012684332

Structure Descriptors

InChI

1S/C24H33N3O7/c1-6-7-13-8-15-21(30)26-17-14(22(31)27(15)10-13)9-16(11(2)18(17)28)34-23-20(29)24(4,32)19(25-5)12(3)33-23/h6-7,9-10,12,15,19-21,23,25-26,28-30,32H,8H2,1-5H3/b7-6+/t12-,15-,19-,20-,21+,23-,24+/m0/s1

InChIKey

RAGFPHFDFVNLCG-INYQBOQCSA-N

Smiles

C/C=C/C1=CN2[C@@H](C1)[C@H](Nc3c(cc(c(c3O)C)O[C@H]4[C@@H]([C@]([C@H]([C@@H](O4)C)NC)(C)O)O)C2=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD10 intravenous 5ug/kg (0.005mg/kg) CARDIAC: OTHER CHANGES

CARDIAC: PERICARDITIS
Antibiotiki. Vol. 15, Pg. 612, 1970.
mouse LD50 intraperitoneal 32ug/kg (0.032mg/kg)   Antibiotiki. Vol. 15, Pg. 612, 1970.
mouse LD50 intravenous 58ug/kg (0.058mg/kg)   Antibiotiki. Vol. 15, Pg. 612, 1970.
mouse LD50 oral 459ug/kg (0.459mg/kg)   Antibiotiki. Vol. 15, Pg. 612, 1970.
mouse LD50 subcutaneous 84ug/kg (0.084mg/kg)   Antibiotiki. Vol. 15, Pg. 612, 1970.
rabbit LD10 intravenous 12ug/kg (0.012mg/kg) BLOOD: OTHER CHANGES Antibiotiki. Vol. 15, Pg. 612, 1970.
rat LD50 intraperitoneal 6ug/kg (0.006mg/kg)   Antibiotiki. Vol. 15, Pg. 612, 1970.
rat LD50 intravenous 29ug/kg (0.029mg/kg)   Antibiotiki. Vol. 15, Pg. 612, 1970.