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Substance Name: Hydroxyurea [USAN:USP]
RN: 127-07-1
UNII: X6Q56QN5QC
InChIKey: VSNHCAURESNICA-UHFFFAOYSA-N
Note
- An antineoplastic agent that inhibits DNA synthesis through the inhibition of ribonucleoside diphosphate reductase.
Molecular Formula
- C-H4-N2-O2
Molecular Weight
- 76.0546
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
- Antineoplastic
- Antineoplastic Agents
- Antisickling Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Hematologic Agents
- Human Data
- Mutation Data
- Nucleic Acid Synthesis Inhibitors
- Reproductive Effect
- Skin / Eye Irritant
- Tumor Data
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Names and Synonyms
Name of Substance
- Hydroxycarbamide [INN]
- Hydroxyurea
- Hydroxyurea [USAN:USP]
MeSH Heading
- Hydroxyurea
Synonyms
- 4-03-00-00170 (Beilstein Handbook Reference)
- AI3-51139
- Biosupressin
- BRN 1741548
- Carbamohydroxamic acid
- Carbamohydroximic acid
- Carbamoyl oxime
- Carbamyl hydroxamate
- CCRIS 958
- Droxia
- EINECS 204-821-7
- Hidrix
- Hidroxicarbamida
- Hidroxicarbamida [INN-Spanish]
- HSDB 6887
- HU
- Hydrea
- Hydroxicarbamidum
- Hydroxycarbamide
- Hydroxycarbamidum
- Hydroxycarbamidum [INN-Latin]
- Hydroxycarbamine
- Hydroxyharnstoff
- Hydroxyharnstoff [German]
- Hydroxylamine, N-(aminocarbonyl)-
- Hydroxylamine, N-carbamoyl-
- Hydroxyurea
- Hydura
- Hydurea
- Idrossicarbamide
- Idrossicarbamide [DCIT]
- Litalir
- N-Carbamoylhydroxylamine
- N-Hydroxymocovina
- N-Hydroxymocovina [Czech]
- N-Hydroxyurea
- NCI-C04831
- NSC 32065
- Onco-Carbide
- Oxyurea
- Siklos
- SK 22591
- SQ 1089
- UNII-X6Q56QN5QC
Systematic Names
- Hydroxyurea
- Urea, hydroxy-
Superlist Name
- Hydroxyurea
Registry Numbers
CAS Registry Number
- 127-07-1
FDA UNII
- X6Q56QN5QC
System Generated Number
- 0000127071
Structure Descriptors
InChI
1S/CH4N2O2/c2-1(4)3-5/h5H,(H3,2,3,4)InChIKey
VSNHCAURESNICA-UHFFFAOYSA-NSmiles
C(NO)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LD50 | intravenous | > 1gm/kg (1000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
dog | LD50 | oral | > 2gm/kg (2000mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
human | TDLo | intravenous | 86mg/kg (86mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BLOOD: OTHER CHANGES | Cancer Chemotherapy Reports, Part 1. Vol. 57, Pg. 369, 1973. |
human | TDLo | oral | 80mg/kg/D (80mg/kg) | BLOOD: NORMOCYTIC ANEMIA BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA | Cancer Chemotherapy Reports. Vol. 29, Pg. 103, 1963. |
man | TDLo | oral | 14mg/kg (14mg/kg) | Annals of Pharmacotherpy. Vol. 29, Pg. 132, 1995. | |
man | TDLo | oral | 450mg/kg/21D- (450mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING LUNGS, THORAX, OR RESPIRATION: "FIBROSIS, FOCAL (PNEUMOCONIOSIS)" | Netherlands Journal of Medicine. Vol. 51, Pg. 110, 1997. |
man | TDLo | unreported | 64mg/kg/3D-I (64mg/kg) | LUNGS, THORAX, OR RESPIRATION: DYSPNEA LUNGS, THORAX, OR RESPIRATION: COUGH | Australian and New Zealand Journal of Medicine. Vol. 28, Pg. 347, 1998. |
mouse | LD10 | subcutaneous | 2400mg/kg (2400mg/kg) | European Journal of Cancer. Vol. 10, Pg. 667, 1974. | |
mouse | LD50 | intraperitoneal | 5800mg/kg (5800mg/kg) | Cancer Research. Vol. 39, Pg. 3575, 1979. | |
mouse | LD50 | intravenous | 2350mg/kg (2350mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
mouse | LD50 | oral | 7330mg/kg (7330mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
rat | LD50 | intraperitoneal | > 4700mg/kg (4700mg/kg) | Arzneimittel-Forschung. Drug Research. Vol. 18, Pg. 645, 1968. | |
rat | LD50 | intravenous | 4730mg/kg (4730mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
rat | LD50 | oral | 5760mg/kg (5760mg/kg) | Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 23, Pg. 682, 1992. | |
rat | LD50 | unreported | 4300mg/kg (4300mg/kg) | Proceedings of the American Association for Cancer Research. Vol. 4, Pg. 10, 1963. | |
women | TDLo | oral | 600mg/kg/30D- (600mg/kg) | Netherlands Journal of Medicine. Vol. 51, Pg. 110, 1997. | |
women | TDLo | oral | 600mg/kg/30D- (600mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" | Netherlands Journal of Medicine. Vol. 51, Pg. 110, 1997. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 141 | deg C | EXP | |
log P (octanol-water) | -1.80E+00 | (none) | EXP | |
Water Solubility | 1.00E+06 | mg/L | 25 | EXP |
Vapor Pressure | 2.43E-03 | mm Hg | 25 | EST |
Henry's Law Constant | 5.42E-11 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.00E-12 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.