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Substance Name: Tetrachloroethylene [USP]
RN: 127-18-4
UNII: TJ904HH8SN
InChIKey: CYTYCFOTNPOANT-UHFFFAOYSA-N

Note

  • A chlorinated hydrocarbon used as an industrial solvent and cooling liquid in electrical transformers. It is a potential carcinogen.

Molecular Formula

  • C2-Cl4

Molecular Weight

  • 165.834
 

Classification Codes

Classification Codes

  • Agricultural Chemical
  • Carcinogens
  • Drug / Therapeutic Agent
  • Environmental Pollutants
  • Fungicide, Bactericide, Wood Preservative
  • Human Data
  • Insecticide
  • Mutation Data
  • Nematocide
  • Noxae
  • Reproductive Effect
  • Skin / Eye Irritant
  • Solvents
  • Tumor Data

Superlist Classification Codes

  • 2007 CERCLA Priority List, Rank: 33
  • 2011 CERCLA Priority List, Rank: 33
  • Overall Carcinogenic Evaluation: Group 2A
  • Reasonably Anticipated to be a Carcinogen
  • Reportable Quantity (RQ) = 100 lb
  • TWA (25 ppm); STEL (100 ppm); Confirmed animal carcinogen with unknown relevance to humans; BEI
  • TWA 100 mg/m3; Ceiling 200 mg/m3, peak 300 in 5 min in any;

Names and Synonyms

Name of Substance

  • Tetrachloroethylene
  • Tetrachloroethylene [USP]

MeSH Heading

  • Tetrachloroethylene

Synonyms

  • 1,1,2,2-Tetrachloroethene
  • 1,1,2,2-Tetrachloroethylene
  • 4-01-00-00715 (Beilstein Handbook Reference)
  • AI3-01860
  • Ankilostin
  • Antisol 1
  • BRN 1361721
  • Carbon bichloride
  • Carbon dichloride
  • Caswell No. 827
  • CCRIS 579
  • Czterochloroetylen
  • Czterochloroetylen [Polish]
  • Didakene
  • Dilatin PT
  • Dow-per
  • EC 204-825-9
  • EINECS 204-825-9
  • ENT 1,860
  • EPA Pesticide Chemical Code 078501
  • Ethene, tetrachloro-
  • Ethylene tetrachloride
  • Ethylene, tetrachloro-
  • Fedal-UN
  • HSDB 124
  • NCI-C04580
  • NSC 9777
  • PCE
  • Perawin
  • Perc
  • Perchloorethyleen, per
  • Perchloorethyleen, per [Dutch]
  • Perchlor
  • Perchloraethylen, per
  • Perchloraethylen, per [German]
  • Perchlorethylene
  • Perchlorethylene, per
  • Perchlorethylene, per [French]
  • Perchloroethylene
  • Perclene
  • Perclene D
  • Percloroetilene
  • Percloroetilene [Italian]
  • Percosolv
  • Percosolve
  • PERK
  • Perklone
  • Persec
  • RCRA waste number U210
  • Tetlen
  • Tetracap
  • Tetrachlooretheen
  • Tetrachlooretheen [Dutch]
  • Tetrachloraethen
  • Tetrachloraethen [German]
  • Tetrachlorethylene
  • Tetrachloroethene
  • Tetrachloroethylene
  • Tetrachloroethylene (IUPAC)
  • Tetracloroetene
  • Tetracloroetene [Italian]
  • Tetraguer
  • Tetraleno
  • Tetralex
  • Tetravec
  • Tetroguer
  • Tetropil
  • UN 1897
  • UNII-TJ904HH8SN

Systematic Names

  • 1,1,2,2-Tetrachloroethylene
  • Ethene, 1,1,2,2-tetrachloro-
  • Ethene, tetrachloro-
  • Ethylene, tetrachloro-
  • Tetrachloroethylene

Superlist Names

  • 1,1,2,2-Tetrachloroethylene
  • Ethene, tetrachloro-
  • Ethylene, tetrachloro-
  • Perchloroethylene
  • RCRA waste no. U210
  • Tetrachloroethene
  • Tetrachloroethylene
  • Tetrachloroethylene [UN1897] [Poison]
  • UN1897

Registry Numbers

CAS Registry Number

  • 127-18-4

FDA UNII

  • TJ904HH8SN

System Generated Number

  • 0000127184

Structure Descriptors

InChI

1S/C2Cl4/c3-1(4)2(5)6

InChIKey

CYTYCFOTNPOANT-UHFFFAOYSA-N

Smiles

C(=C(\Cl)Cl)(\Cl)Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 4gm/kg (4000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: SLEEP
American Journal of Hygiene. Vol. 9, Pg. 430, 1929.
child TDLo oral 545mg/kg (545mg/kg) BEHAVIORAL: COMA Journal of Toxicology, Clinical Toxicology. Vol. 23, Pg. 103, 1985.
dog LD50 intraperitoneal 2100mg/kg (2100mg/kg) LIVER: LIVER FUNCTION TESTS IMPAIRED Toxicology and Applied Pharmacology. Vol. 10, Pg. 119, 1967.
dog LDLo intravenous 85mg/kg (85mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
dog LDLo oral 4gm/kg (4000mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
American Journal of Hygiene. Vol. 9, Pg. 430, 1929.
human TCLo inhalation 96ppm/7H (96ppm) BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS"

PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC

SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE
National Technical Information Service. Vol. PB257-185,
man TCLo inhalation 600ppm/10M (600ppm) SENSE ORGANS AND SPECIAL SENSES: CONJUNCTIVE IRRITATION: EYE

BEHAVIORAL: GENERAL ANESTHETIC
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 5, Pg. 566, 1952.
mouse LC50 inhalation 5200ppm/4H (5200ppm)   Acta Pharmacologica et Toxicologica. Vol. 9, Pg. 303, 1953.
mouse LD intraperitoneal > 500mg/kg (500mg/kg)   "Summary Tables of Biological Tests," National Research Council Chemical-Biological Coordination Center. Vol. 4, Pg. 378, 1952.
mouse LD50 oral 8100mg/kg (8100mg/kg) BEHAVIORAL: GENERAL ANESTHETIC National Technical Information Service. Vol. PB257-185,
mouse LD50 subcutaneous 65gm/kg (65000mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: SLEEP
Journal of Pharmacology and Experimental Therapeutics. Vol. 123, Pg. 224, 1958.
rabbit LD skin > 3228mg/kg (3228mg/kg)   National Technical Information Service. Vol. AD-A180-198,
rabbit LDLo oral 5gm/kg (5000mg/kg) BEHAVIORAL: SLEEP

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
American Journal of Hygiene. Vol. 9, Pg. 430, 1929.
rabbit LDLo subcutaneous 2200mg/kg (2200mg/kg)   Quarterly Journal of Pharmacy & Pharmacology. Vol. 7, Pg. 205, 1934.
rat LC50 inhalation 34200mg/m3/8H (34200mg/m3)   American Industrial Hygiene Association Journal. Vol. 20, Pg. 364, 1959.
rat LD50 intraperitoneal 4678mg/kg (4678mg/kg)   Environmental Research. Vol. 40, Pg. 411, 1986.
rat LD50 oral 2629mg/kg (2629mg/kg)   American Industrial Hygiene Association Journal. Vol. 20, Pg. 364, 1959.
rat LDLo intratracheal 450mg/kg (450mg/kg)   National Technical Information Service. Vol. OTS0520615,

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -2.23E+01 deg C   EXP
Boiling Point 121.3 deg C   EXP
log P (octanol-water) 3.4 (none)   EXP
Water Solubility 206 mg/L 25 EXP
Vapor Pressure 18.5 mm Hg 25 EXP
Henry's Law Constant 0.0177 atm-m3/mole 24 EXP
Atmospheric OH Rate Constant 1.67E-13 cm3/molecule-sec 25 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.