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Substance Name: N,N-Dimethylacetamide
RN: 127-19-5
UNII: JCV5VDB3HY
InChIKey: FXHOOIRPVKKKFG-UHFFFAOYSA-N

Molecular Formula

  • C4-H9-N-O

Molecular Weight

  • 87.1211
 

Classification Codes

Classification Codes

  • Cryoprotective Agents
  • Drug / Therapeutic Agent
  • Mutation Data
  • Protective Agents
  • Reproductive Effect
  • Skin / Eye Irritant

Superlist Classification Codes

  • TWA (10 ppm); Skin; Not classifiable as a human carcinogen; BEI
  • TWA 10 ppm3 (35 mg/m3); skin

Names and Synonyms

Name of Substance

  • Dimethylacetamide
  • N,N-Dimethylacetamide

Synonyms

  • Acetamide, N,N-dimethyl-
  • Acetdimethylamide
  • Acetic acid, dimethylamide
  • Acetyldimethylamine
  • AI3-15276
  • CBC 510337
  • CCRIS 4623
  • Dimethylacetamide
  • Dimethylacetone amide
  • Dimethylamid kyseliny octove
  • Dimethylamid kyseliny octove [Czech]
  • Dimethylamide acetate
  • DMA
  • DMAc
  • EC 204-826-4
  • EINECS 204-826-4
  • HSDB 74
  • N,N-Dimethylacetamide
  • N,N-Dimethylethanamide
  • NSC 3138
  • SK 7176
  • U-5954
  • UNII-JCV5VDB3HY

Systematic Names

  • Acetamide, N,N-dimethyl-
  • Dimethylacetamide
  • N,N-Dimethylacetamide

Superlist Names

  • Acetamide, N,N-dimethyl-
  • Dimethyl acetamide
  • Dimethylacetamide
  • N,N-Dimethylacetamide
  • N,N-Dimethylacetamide solution
  • N,N-Dimethylacetamide solution (40% or less)

Registry Numbers

CAS Registry Number

  • 127-19-5

FDA UNII

  • JCV5VDB3HY

System Generated Number

  • 0000127195

Structure Descriptors

InChI

1S/C4H9NO/c1-4(6)5(2)3/h1-3H3

InChIKey

FXHOOIRPVKKKFG-UHFFFAOYSA-N

Smiles

CC(=O)N(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LDLo intravenous 12gm/kg (12000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
mammal (species unspecified) LCLo inhalation 406ppm (406ppm) LIVER: FATTY LIVER DEGERATION Toxicology and Applied Pharmacology. Vol. 3, Pg. 12, 1961.
mouse LC50 inhalation 7200mg/m3 (7200mg/m3) LIVER: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: ATAXIA
Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 13, Pg. 29, 1979.
mouse LD50 intraperitoneal 2800mg/kg (2800mg/kg)   Yokohama Igaku. Yokohama Medicine. Vol. 31, Pg. 327, 1980.
mouse LD50 intravenous 3020mg/kg (3020mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 oral 4620mg/kg (4620mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
mouse LD50 skin 9600mg/kg (9600mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LIVER: OTHER CHANGES

BEHAVIORAL: FOOD INTAKE (ANIMAL)
Zhonghua Yufangyixue Zazhi. Chinese Journal of Preventive Medicine. Vol. 13, Pg. 29, 1979.
rabbit LD50 skin 2240mg/kg (2240mg/kg) SKIN AND APPENDAGES (SKIN): PRIMARY IRRITATION: AFTER TOPICAL EXPOSURE American Industrial Hygiene Association Journal. Vol. 23, Pg. 95, 1962.
rabbit LDLo intravenous 8340mg/kg (8340mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 20, Pg. 1242, 1970.
rat LC50 inhalation 2475ppm/1H (2475ppm)   Drug and Chemical Toxicology. Vol. 9, Pg. 147, 1986.
rat LD50 intraperitoneal 2750mg/kg (2750mg/kg)   Journal of Reproduction and Fertility. Vol. 4, Pg. 219, 1962.
rat LD50 intravenous 2640mg/kg (2640mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 26, Pg. 1581, 1976.
rat LD50 oral 4300mg/kg (4300mg/kg)   Gigiena i Sanitariya. For English translation, see HYSAAV. Vol. 45(6), Pg. 76, 1980.
rat LD50 skin > 2gm/kg (2000mg/kg)   United States Environmental Protection Agency, Office of Pesticides and Toxic Substances. Vol. 8EHQ-1190-0981,
rat LD50 unreported 3gm/kg (3000mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 19, Pg. 1073, 1969.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point -2.00E+01 deg C   EXP
Boiling Point 165 deg C   EXP
pKa Dissociation Constant 10.78 (none) 25 EXP
log P (octanol-water) -0.77 (none)   EXP
Water Solubility 1.00E+06 mg/L 25 EXP
Vapor Pressure 2 mm Hg 25 EXP
Henry's Law Constant 1.31E-08 atm-m3/mole 25 EXP
Atmospheric OH Rate Constant 1.36E-11 cm3/molecule-sec 27 EXP

Physical property data is provided to ChemIDplus by SRC, Inc.