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Substance Name: Fludrocortisone [INN:BAN]
RN: 127-31-1
UNII: U0476M545B
InChIKey: AAXVEMMRQDVLJB-BULBTXNYSA-N

Note

  • A synthetic mineralocorticoid with anti-inflammatory activity.

Molecular Formula

  • C21-H29-F-O5

Molecular Weight

  • 380.4531
 

Classification Codes

  • Anti-Inflammatory Agents
  • Drug / Therapeutic Agent
  • Hormone
  • Reproductive Effect

Names and Synonyms

Name of Substance

  • Fludrocortisone
  • Fludrocortisone [INN:BAN]

MeSH Heading

  • Fludrocortisone

Synonyms

  • 4-08-00-03427 (Beilstein Handbook Reference)
  • 9 alpha FF
  • 9-AF
  • 9-AFH
  • 9-alpha-Fludrocortisone
  • 9-alpha-Fluoro-17-hydroxycorticosterone
  • 9-alpha-Fluorocortisol
  • 9-alpha-Fluorohydrocortisone
  • 9-Fluoro-11-beta,17,21-trihydroxypregn-4-ene-3,20-dione
  • 9-Fluoro-11beta,17,21-trihydroxypregn-4-ene-3,20-dione
  • 9alpha-Fludrocortisone
  • 9alpha-Fluoro-11beta,17alpha,21-trihydroxy-4-pregnene-3,20-dione
  • 9alpha-Fluoro-17-hydroxycorticosterone
  • 9alpha-Fluoro-hydrocortisone
  • 9alpha-Fluorocortisol
  • Alflorone
  • Astonin-H
  • BRN 3014278
  • Corticosterone, 9-fluoro-17-hydroxy-
  • Cortisol, 9-fluoro-
  • EINECS 204-833-2
  • F-COL
  • F-Cortef
  • Florinef
  • Fludrocortisona
  • Fludrocortisona [INN-Spanish]
  • Fludrocortisone
  • Fludrocortisonum
  • Fludrocortisonum [INN-Latin]
  • Fludrocortone
  • Fludrone
  • Fludronef
  • Fluodrocortisone
  • Fluohydrisone
  • Fluohydrocortisone
  • Fluorocortisol
  • Fluorocortisone
  • HSDB 3332
  • Hydrocortisone-9alpha-fluoro
  • NSC 11318
  • Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11beta)-
  • Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-
  • StC 1400
  • U 5963
  • UNII-U0476M545B

Systematic Names

  • Fludrocortisone
  • Pregn-4-ene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-, (11beta)-
  • Pregn-4-ene-3,20-dione, 9-fluoro-11-beta,17,21-trihydroxy-
  • Pregn-4-ene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy- (8CI)

Registry Numbers

CAS Registry Number

  • 127-31-1

FDA UNII

  • U0476M545B

System Generated Number

  • 0000127311

Structure Descriptors

InChI

1S/C21H29FO5/c1-18-7-5-13(24)9-12(18)3-4-15-14-6-8-20(27,17(26)11-23)19(14,2)10-16(25)21(15,18)22/h9,14-16,23,25,27H,3-8,10-11H2,1-2H3/t14-,15-,16-,18-,19-,20-,21-/m0/s1

InChIKey

AAXVEMMRQDVLJB-BULBTXNYSA-N

Smiles

C[C@]12CCC(=O)C=C1CC[C@@H]3[C@@]2([C@H](C[C@]4([C@H]3CC[C@@]4(C(=O)CO)O)C)O)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 170mg/kg (170mg/kg)   Compilation of LD50 Values of New Drugs.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.67 (none)   EXP
Water Solubility 140 mg/L 25 EXP
Vapor Pressure 1.65E-13 mm Hg 25 EST
Henry's Law Constant 1.15E-07 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.08E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.