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Substance Name: Phenazocine [INN:BAN]
RN: 127-35-5
InChIKey: ZQHYKVKNPWDQSL-UHFFFAOYSA-N

Note

  • An opioid analgesic with actions and uses similar to MORPHINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1095)

Molecular Formula

  • C22-H27-N-O

Molecular Weight

  • 321.4613
 

Classification Codes

Classification Codes

  • Analgesics
  • Analgesics, Opioid
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Human Data
  • Narcotics
  • Peripheral Nervous System Agents
  • Sensory System Agents

Superlist Classification Code

  • DEA Schedule II
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Names and Synonyms

Name of Substance

  • Phenazocine
  • Phenazocine [INN:BAN]

MeSH Heading

  • Phenazocine

Synonyms

  • 1,2,3,4,5,6-Hexahydro-6,11-dimethyl-3-phenethyl-2,6-methano-3-benzazocin-8-ol
  • 1,2,3,4,5,6-Hexahydro-8-hydroxy-6,11-dimethyl-3-phenethyl-2,6-methano-3-benzazocine
  • 2'-Hydroxy-5,9-dimethyl-2-phenethyl-6,7-benzomorphan
  • 6,11-Dimethyl-1,2,3,4,5,6-hexahydro-8-hydroxy-3-phenethyl-2,6-methano-3-benzazocine
  • EINECS 204-835-3
  • Fenazocina
  • Fenazocina [INN-Spanish]
  • NIH 7519
  • Phenazocine
  • Phenazocinum
  • Phenazocinum [INN-Latin]
  • Prinadol
  • SKF 6574

Systematic Names

  • 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-(2-phenylethyl)-
  • 2,6-Methano-3-benzazocin-8-ol, 1,2,3,4,5,6-hexahydro-6,11-dimethyl-3-phenethyl-
  • Phenazocine

Superlist Names

  • DEA No. 9715
  • Phenazocine

Registry Numbers

CAS Registry Number

  • 127-35-5

Related Registry Number

  • 1239-04-9 (hydrobromide)

System Generated Number

  • 0000127355

Structure Descriptors

InChI

1S/C22H27NO/c1-16-21-14-18-8-9-19(24)15-20(18)22(16,2)11-13-23(21)12-10-17-6-4-3-5-7-17/h3-9,15-16,21,24H,10-14H2,1-2H3

InChIKey

ZQHYKVKNPWDQSL-UHFFFAOYSA-N

Smiles

CC1C2Cc3ccc(cc3C1(CCN2CCc4ccccc4)C)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
human TDLo intramuscular 29ug/kg (0.029mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION New York State Journal of Medicine. Vol. 61, Pg. 83, 1961.
mouse LD50 intraperitoneal 56mg/kg (56mg/kg)   Research Progress in Organic-Biological and Medicinal Chemistry. Vol. 2, Pg. 309, 1970.
mouse LD50 intravenous 20mg/kg (20mg/kg)   U.S. Army Armament Research & Development Command, Chemical Systems Laboratory, NIOSH Exchange Chemicals. Vol. NX#02061,
rat LD50 oral 90mg/kg (90mg/kg)   Drug Development Research. Vol. 1, Pg. 1, 1981.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 181 deg C   EXP
log P (octanol-water) 5.200 (none)   EST
Atmospheric OH Rate Constant 2.16E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.