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Substance Name: Pazufloxacin [INN]
RN: 127045-41-4
UNII: 4CZ1R38NDI
InChIKey: XAGMUUZPGZWTRP-ZETCQYMHSA-N

Molecular Formula

  • C16-H15-F-N2-O4

Molecular Weight

  • 318.3025
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antineoplastic Agents
  • Antitubercular Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Reproductive Effect
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors
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Names and Synonyms

Name of Substance

  • Pazufloxacin
  • Pazufloxacin [INN]

Synonyms

  • (-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
  • CCRIS 7312
  • Pazufloxacin
  • T 3761
  • UNII-4CZ1R38NDI

Systematic Names

  • (-)-(3S)-10-(1-Aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-7H-pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid
  • 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 10-(1-aminocyclopropyl)-9-fluoro-2,3-dihydro-3-methyl-7-oxo-, (S)-
  • 7H-Pyrido(1,2,3-de)-1,4-benzoxazine-6-carboxylic acid, 2,3-dihydro-10-(1-aminocyclopropyl)-9-fluoro-3-methyl-7-oxo-, (S)-
  • T-3761

Registry Numbers

CAS Registry Number

  • 127045-41-4

FDA UNII

  • 4CZ1R38NDI

System Generated Number

  • 0127045414

Structure Descriptors

InChI

1S/C16H15FN2O4/c1-7-6-23-14-11(16(18)2-3-16)10(17)4-8-12(14)19(7)5-9(13(8)20)15(21)22/h4-5,7H,2-3,6,18H2,1H3,(H,21,22)/t7-/m0/s1

InChIKey

XAGMUUZPGZWTRP-ZETCQYMHSA-N

Smiles

C[C@H]1COc2c(c(cc3c2n1cc(c3=O)C(=O)O)F)C4(CC4)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 2gm/kg (2000mg/kg)   Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995.
dog LDLo intravenous 400mg/kg (400mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

GASTROINTESTINAL: NAUSEA OR VOMITING
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995.
mouse LD oral > 5gm/kg (5000mg/kg)   Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995.
mouse LD subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995.
mouse LD50 intravenous 783mg/kg (783mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995.
rat LD oral > 5gm/kg (5000mg/kg)   Chemotherapy Vol. 43(Suppl,
rat LD subcutaneous > 5gm/kg (5000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995.
rat LD50 intravenous 341mg/kg (341mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Japanese Journal of Antibiotics. Vol. 48, Pg. 754, 1995.