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Substance Name: Balofloxacin [INN]
RN: 127294-70-6
UNII: Q022B63JPM
InChIKey: MGQLHRYJBWGORO-UHFFFAOYSA-N

Note

  • Showed potent bactericidal activity & inhibited the supercoiling activity of DNA gyrase of S. aureus, E. coli, & P aeruginosa.

Molecular Formula

  • C20-H24-F-N3-O4

Molecular Weight

  • 389.4246
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
  • Reproductive Effect
  • Topoisomerase II Inhibitors
  • Topoisomerase Inhibitors
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Names and Synonyms

Name of Substance

  • Balofloxacin
  • Balofloxacin [INN]

Synonyms

  • (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-(methylamino)piperidino)-4-oxo-3-quinolinecarboxylic acid
  • Balofloxacin
  • Q 35
  • UNII-Q022B63JPM

Systematic Names

  • (+-)-1-Cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-(methylamino)piperidino)-4-oxo-3-quinolinecarboxylic acid
  • 3-Quinolinecarboxylic acid, 1-cyclopropyl-6-fluoro-1,4-dihydro-8-methoxy-7-(3-(methylamino)-1-piperidinyl)-4-oxo-

Registry Numbers

CAS Registry Number

  • 127294-70-6

FDA UNII

  • Q022B63JPM

Other Registry Number

  • 165619-85-2

System Generated Number

  • 0127294706

Structure Descriptors

InChI

1S/C20H24FN3O4/c1-22-11-4-3-7-23(9-11)17-15(21)8-13-16(19(17)28-2)24(12-5-6-12)10-14(18(13)25)20(26)27/h8,10-12,22H,3-7,9H2,1-2H3,(H,26,27)

InChIKey

MGQLHRYJBWGORO-UHFFFAOYSA-N

Smiles

CNC1CCCN(C1)c2c(cc3c(c2OC)n(cc(c3=O)C(=O)O)C4CC4)F

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LDLo oral > 400mg/kg (400mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: NAUSEA OR VOMITING
Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,
mouse LD oral > 5gm/kg (5000mg/kg)   Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,
rat LDLo oral > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Yakuri to Chiryo. Pharmacology and Therapeutics. Vol. 23(Suppl,