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Substance Name: Sivelestat [USAN:INN]
RN: 127373-66-4
UNII: DWI62G0P59
InChIKey: BTGNGJJLZOIYID-UHFFFAOYSA-N

Note

  • Inhibitor of neutrophil elastase.

Molecular Formula

  • C20-H22-N2-O7-S

Molecular Weight

  • 434.4668
 

Classification Codes

  • Acute Respiratory Distress Syndrome (Elastase Inhibitor)
  • Enzyme Inhibitors
  • Protease Inhibitors
  • Serine Proteinase Inhibitors
  • Treatment of Acute Lung Injury
  • Treatment of Acute Lung Injury; Acute Respiratory Distress Syndrome (Elastase Inhibitor)
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Names and Synonyms

Name of Substance

  • Sivelestat
  • Sivelestat [USAN:INN]

Synonyms

  • EI 546
  • Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-
  • LY 544349
  • LY544349
  • N-(2-(4-(2,2-Dimethylpropionyloxy)phenylsulfonylamino)benzoyl)aminoacetic acid
  • o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester)
  • Ono-5046
  • ONO-5046.Na
  • ONO5046
  • Sivelestat
  • UNII-DWI62G0P59

Systematic Names

  • Glycine, N-(2-(((4-(2,2-dimethyl-1-oxopropoxy)phenyl)sulfonyl)amino)benzoyl)-
  • o-(p-Hydroxybenzenesulfonamido)hippuric acid, pivalate (ester)

Registry Numbers

CAS Registry Number

  • 127373-66-4

FDA UNII

  • DWI62G0P59

System Generated Number

  • 0127373664

Structure Descriptors

InChI

InChI=1S/C20H22N2O7S/c1-20(2,3)19(26)29-13-8-10-14(11-9-13)30(27,28)22-16-7-5-4-6-15(16)18(25)21-12-17(23)24/h4-11,22H,12H2,1-3H3,(H,21,25)(H,23,24)

InChIKey

BTGNGJJLZOIYID-UHFFFAOYSA-N

Smiles

CC(C)(C)C(=O)Oc1ccc(cc1)S(=O)(=O)Nc2ccccc2C(=O)NCC(=O)O