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Substance Name: Propagermanium [INN]
RN: 12758-40-6
UNII: 1Q2P9TO9Q7
InChIKey: XEABSBMNTNXEJM-UHFFFAOYSA-N

Note

  • Inhibits the calcium inward currents & the potassium outward currents.

Molecular Formula

  • C6-H10-Ge2-O7

Molecular Weight

  • 339.358
 

Classification Codes

  • Antineoplastic Agents
  • Drug / Therapeutic Agent
  • Immunologic Factors
  • Interferon Inducers
  • Mutation Data
  • Reproductive Effect
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Names and Synonyms

Results Name

  • Propagermanium [INN]

Name of Substance

  • Propagermanium
  • Propagermanium [INN]
  • Proxigermanium
  • Repagermanium [INN]

Synonyms

  • 14C-Proxigermanium
  • 2-(Carboxyethyl)germanium sesquioxide
  • 2-Carboxyethylgermasesquioxane
  • 3,3'-(Dioxodigermoxanylene) dipropanoic acid
  • 3,3'-(Germanoic anhydride) dipropanoic acid
  • Bis-beta-carboxyethylgermanium sesquioxide
  • BRN 4141883
  • Carboxyethylgermanium sesquioxide
  • Carboxylethylgermanium sesquioxide
  • CCRIS 5469
  • Dipropanoic acid germanium sequioxide
  • EINECS 235-800-0
  • Ge 132
  • NSC 267004
  • Propagermanium
  • Propanoic acid, 3,3'-(oxybis(oxogermylene))bis-
  • Propionic acid, 3,3'-(1,3-dioxodigermoxanylene)di-
  • Proxigermanium
  • Repagermanium
  • SK 818
  • UNII-1Q2P9TO9Q7

Systematic Names

  • 3,3'-(1,3-Dioxo-1,3-digermoxanediyl)dipropionic acid
  • Carboxyethylgermanium sesquioxide
  • Dihydrogen bis(2-carboxylatoethyl)trioxodigermanate(2-)
  • Germanate(2-), bis(2-carboxylatoethyl)trioxodi-, dihydrogen (9CI)
  • Propanoic acid, 3,3'-(1,3-dioxo-1,3-digermoxanediyl)bis-

Registry Numbers

CAS Registry Number

  • 12758-40-6

FDA UNII

  • 1Q2P9TO9Q7

Other Registry Numbers

  • 122402-75-9
  • 27031-31-8
  • 31434-91-0
  • 69992-83-2
  • 83172-76-3

System Generated Number

  • 0012758406

Structure Descriptors

InChI

1S/C6H10Ge2O7/c9-5(10)1-3-7(13)15-8(14)4-2-6(11)12/h1-4H2,(H,9,10)(H,11,12)

InChIKey

XEABSBMNTNXEJM-UHFFFAOYSA-N

Smiles

C(C[Ge](=O)O[Ge](=O)CCC(=O)O)C(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 4gm/kg (4000mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 19, 1990.
mouse LD50 intraperitoneal 1250mg/kg (1250mg/kg) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
mouse LD50 intravenous > 200mg/kg (200mg/kg)   Drugs in Japan Vol. -, Pg. 1195, 1995.
mouse LD50 oral 5600mg/kg (5600mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
mouse LD50 subcutaneous > 4gm/kg (4000mg/kg)   Drugs in Japan Vol. -, Pg. 1195, 1995.
rat LD50 intraperitoneal 1670mg/kg (1670mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
rat LD50 intravenous > 200mg/kg (200mg/kg)   Drugs in Japan Vol. -, Pg. 1195, 1995.
rat LD50 oral 7050mg/kg (7050mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.
rat LD50 subcutaneous > 4gm/kg (4000mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Kiso to Rinsho. Clinical Report. Vol. 24, Pg. 5, 1990.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 270 dec deg C   EXP
pKa Dissociation Constant 3.6 (none)   EXP
log P (octanol-water) 0.750 (none)   EST
Water Solubility 1.09E+04 mg/L 20 EXP
Atmospheric OH Rate Constant 2.57E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.