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Substance Name: Monorden
RN: 12772-57-5
UNII: I60EH8GECX
InChIKey: WYZWZEOGROVVHK-GTMNPGAYSA-N

Note

  • Inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II.

Molecular Formula

  • C18-H17-Cl-O6

Molecular Weight

  • 364.7793
 

Classification Codes

  • Anti-Infective Agents
  • Antifungal Agents
  • Antimalarials
  • Antiparasitic Agents
  • Antiprotozoal Agents
  • Drug / Therapeutic Agent
  • Enzyme Inhibitors
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Names and Synonyms

Name of Substance

  • Monorden

Synonyms

  • (+)-Monorden A
  • Monorden
  • Monorden A
  • Monorderne
  • NSC 294404
  • Radicicol
  • Radicicol R 2146
  • Radicolol
  • Radisicol
  • RHI-12648
  • UNII-I60EH8GECX

Systematic Name

  • 6H-Oxireno(e)(2)benzoxacyclotetradecin-6,12(7H)-dione, 8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-

Registry Numbers

CAS Registry Number

  • 12772-57-5

FDA UNII

  • I60EH8GECX

Other Registry Numbers

  • 11021-61-7
  • 5137-90-6
  • 957231-40-2

System Generated Number

  • 0012772575

Structure Descriptors

InChI

1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1

InChIKey

WYZWZEOGROVVHK-GTMNPGAYSA-N

Smiles

C[C@@H]1C[C@H]2O[C@@H]2\C=C/C=C/C(=O)Cc3c(Cl)c(O)cc(O)c3C(=O)O1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 175mg/kg (175mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 448, 1980.
mouse LD50 oral 300mg/kg (300mg/kg)   Journal of Antibiotics. Vol. 48, Pg. 824, 1995.