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Substance Name: Monorden
RN: 12772-57-5
UNII: I60EH8GECX
InChIKey: WYZWZEOGROVVHK-GTMNPGAYSA-N
Note
- Inhibits HSP90 Heat-Shock Proteins, DNA topoisomerase VI and human Topoisomerase II.
Molecular Formula
- C18-H17-Cl-O6
Molecular Weight
- 364.7793
Classification Codes
- Anti-Infective Agents
- Antifungal Agents
- Antimalarials
- Antiparasitic Agents
- Antiprotozoal Agents
- Drug / Therapeutic Agent
- Enzyme Inhibitors
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Names and Synonyms
Name of Substance
- Monorden
Synonyms
- (+)-Monorden A
- Monorden
- Monorden A
- Monorderne
- NSC 294404
- Radicicol
- Radicicol R 2146
- Radicolol
- Radisicol
- RHI-12648
- UNII-I60EH8GECX
Systematic Name
- 6H-Oxireno(e)(2)benzoxacyclotetradecin-6,12(7H)-dione, 8-chloro-1a,14,15,15a-tetrahydro-9,11-dihydroxy-14-methyl-
Registry Numbers
CAS Registry Number
- 12772-57-5
FDA UNII
- I60EH8GECX
Other Registry Numbers
- 11021-61-7
- 5137-90-6
- 957231-40-2
System Generated Number
- 0012772575
Structure Descriptors
InChI
InChI=1S/C18H17ClO6/c1-9-6-15-14(25-15)5-3-2-4-10(20)7-11-16(18(23)24-9)12(21)8-13(22)17(11)19/h2-5,8-9,14-15,21-22H,6-7H2,1H3/b4-2+,5-3-/t9-,14-,15-/m1/s1InChIKey
WYZWZEOGROVVHK-GTMNPGAYSA-NSmiles
C[C@@H]1C[C@H]2O[C@@H]2\C=C/C=C/C(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intravenous | 175mg/kg (175mg/kg) | "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 2, Pg. 448, 1980. | |
mouse | LD50 | oral | 300mg/kg (300mg/kg) | Journal of Antibiotics. Vol. 48, Pg. 824, 1995. |