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Substance Name: Regramostim [USAN:INN]
RN: 127757-91-9
UNII: KR89Q40F01
InChIKey: XDODZSAOGHZLCT-HFNJAKBMSA-N

Note

  • Stimulates the production of a broad range of leukocytes and therefore can cause life-threatening adverse effects at high doses.

Molecular Formula

  • C637-H1003-N171-O187-S8

Molecular Weight

  • 14465.4587
 

Classification Codes

  • Antineutropenic
  • Hematopoietic Stimulant
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Names and Synonyms

Name of Substance

  • Regramostim
  • Regramostim [USAN:INN]

Synonyms

  • GM-CSF
  • GMC 89-107
  • Regramostim
  • Regramostime
  • Regramostime [INN-French]
  • Regramostimum
  • Regramostimum [INN-Latin]
  • rhGm-CSF
  • UNII-KR89Q40F01

Systematic Names

  • A single chain, glycosylated polypeptide of 127 amino acid residues, expressed in Chinese hamster ovary cells. Colony-stimulating factor 2 (human clone pCSF-1 protein moiety reduced), glycoform GMC 89-107
  • Colony-stimulating factor 2 (human clone pCSF-1 protein moiety reduced), glycoform GMC 89-107

Registry Numbers

CAS Registry Number

  • 127757-91-9

FDA UNII

  • KR89Q40F01

System Generated Number

  • 0127757919

Structure Descriptors

InChI

1S/C637H1003N171O197S8/c1-71-318(43)492(782-513(886)328(53)689-548(921)423(267-463(653)840)764-604(977)487(313(33)34)778-580(953)422(266-353-279-671-298-685-353)751-537(910)384(181-202-475(857)858)714-567(940)419(263-350-276-679-359-136-93-91-134-357(350)359)762-595(968)446-151-114-228-800(446)622(995)393(175-196-462(652)839)730-615(988)501(335(60)823)794-588(961)437(289-815)768-597(970)447-152-115-231-803(447)626(999)439(291-817)772-598(971)448-153-116-232-804(448)625(998)438(290-816)771-529(902)368(145-108-222-674-634(661)662)696-511(884)327(52)691-592(965)445-150-113-227-799(445)621(994)322(47)644)607(980)725-375(171-192-458(648)835)530(903)708-379(176-197-470(847)848)518(891)687-325(50)510(883)695-367(144-107-221-673-633(659)660)523(896)700-369(146-109-223-675-635(663)664)526(899)734-403(247-305(17)18)555(928)736-406(250-308(23)24)558(931)755-426(270-466(656)843)573(946)739-407(251-309(25)26)559(932)767-433(285-811)583(956)705-370(147-110-224-676-636(665)666)527(900)757-430(274-486(879)880)581(954)791-496(330(55)818)610(983)692-323(48)508(881)686-324(49)509(882)697-380(177-198-471(849)850)531(904)718-391(212-239-1012-69)542(915)754-424(268-464(654)841)571(944)715-386(183-204-477(861)862)546(919)789-505(339(64)827)619(992)781-489(315(37)38)603(976)724-388(185-206-479(865)866)543(916)777-490(316(39)40)605(978)783-493(319(44)72-2)608(981)769-435(287-813)584(957)716-381(178-199-472(851)852)532(905)719-390(211-238-1011-68)541(914)744-412(256-343-125-82-76-83-126-343)565(938)758-428(272-484(875)876)574(947)740-401(245-303(13)14)553(926)710-373(169-190-456(646)833)533(906)728-394(186-207-480(867)868)623(996)802-230-118-157-452(802)600(973)795-503(337(62)825)618(991)775-442(294-1008)591(964)743-402(246-304(15)16)554(927)711-377(173-194-460(650)837)544(917)787-498(332(57)820)612(985)722-371(148-111-225-677-637(667)668)528(901)733-399(243-301(9)10)552(925)712-383(180-201-474(855)856)536(909)735-404(248-306(19)20)557(930)745-414(260-347-160-164-354(830)165-161-347)561(934)702-362(138-95-101-215-639)520(893)706-372(168-189-455(645)832)517(890)681-280-467(844)693-397(241-299(5)6)549(922)699-361(143-106-220-672-632(657)658)515(888)680-281-468(845)694-431(283-809)582(955)742-409(253-311(29)30)578(951)792-499(333(58)821)613(986)721-366(142-99-105-219-643)525(898)732-398(242-300(7)8)550(923)698-360(137-94-100-214-638)516(889)682-282-469(846)798-226-112-149-444(798)593(966)760-410(254-312(31)32)579(952)793-500(334(59)822)614(987)727-392(213-240-1013-70)540(913)717-389(210-237-1010-67)519(892)688-326(51)512(885)765-432(284-810)585(958)752-420(264-351-277-669-296-683-351)569(942)746-415(261-348-162-166-355(831)167-163-348)562(935)704-363(139-96-102-216-640)521(894)707-374(170-191-457(647)834)535(908)750-421(265-352-278-670-297-684-352)570(943)776-443(295-1009)627(1000)808-236-122-159-454(808)628(1001)805-233-119-158-453(805)601(974)797-507(341(66)829)630(1003)807-235-121-154-449(807)594(967)720-387(184-205-478(863)864)547(920)788-502(336(61)824)617(990)770-436(288-814)587(960)774-440(292-1006)589(962)690-329(54)514(887)786-497(331(56)819)611(984)726-378(174-195-461(651)838)545(918)790-506(340(65)828)620(993)784-494(320(45)73-3)609(982)796-504(338(63)826)616(989)763-417(259-346-131-88-79-89-132-346)563(936)713-385(182-203-476(859)860)539(912)766-434(286-812)586(959)748-411(255-342-123-80-75-81-124-342)560(933)703-364(140-97-103-217-641)522(895)709-382(179-200-473(853)854)538(911)753-425(269-465(655)842)572(945)738-400(244-302(11)12)551(924)701-365(141-98-104-218-642)524(897)756-427(271-483(873)874)575(948)747-413(257-344-127-84-77-85-128-344)564(937)737-405(249-307(21)22)556(929)741-408(252-310(27)28)577(950)779-491(317(41)42)606(979)785-495(321(46)74-4)629(1002)806-234-120-155-450(806)596(969)761-416(258-345-129-86-78-87-130-345)566(939)759-429(273-485(877)878)576(949)773-441(293-1007)590(963)749-418(262-349-275-678-358-135-92-90-133-356(349)358)568(941)729-395(187-208-481(869)870)624(997)801-229-117-156-451(801)599(972)780-488(314(35)36)602(975)723-376(172-193-459(649)836)534(907)731-396(631(1004)1005)188-209-482(871)872/h75-93,123-136,160-167,275-279,296-341,360-454,487-507,678-679,809-831,1006-1009H,71-74,94-122,137-159,168-274,280-295,638-644H2,1-70H3,(H2,645,832)(H2,646,833)(H2,647,834)(H2,648,835)(H2,649,836)(H2,650,837)(H2,651,838)(H2,652,839)(H2,653,840)(H2,654,841)(H2,655,842)(H2,656,843)(H,669,683)(H,670,684)(H,671,685)(H,680,888)(H,681,890)(H,682,889)(H,686,881)(H,687,891)(H,688,892)(H,689,921)(H,690,962)(H,691,965)(H,692,983)(H,693,844)(H,694,845)(H,695,883)(H,696,884)(H,697,882)(H,698,923)(H,699,922)(H,700,896)(H,701,924)(H,702,934)(H,703,933)(H,704,935)(H,705,956)(H,706,893)(H,707,894)(H,708,903)(H,709,895)(H,710,926)(H,711,927)(H,712,925)(H,713,936)(H,714,940)(H,715,944)(H,716,957)(H,717,913)(H,718,904)(H,719,905)(H,720,967)(H,721,986)(H,722,985)(H,723,975)(H,724,976)(H,725,980)(H,726,984)(H,727,987)(H,728,906)(H,729,941)(H,730,988)(H,731,907)(H,732,898)(H,733,901)(H,734,899)(H,735,909)(H,736,928)(H,737,937)(H,738,945)(H,739,946)(H,740,947)(H,741,929)(H,742,955)(H,743,964)(H,744,914)(H,745,930)(H,746,942)(H,747,948)(H,748,959)(H,749,963)(H,750,908)(H,751,910)(H,752,958)(H,753,911)(H,754,915)(H,755,931)(H,756,897)(H,757,900)(H,758,938)(H,759,939)(H,760,966)(H,761,969)(H,762,968)(H,763,989)(H,764,977)(H,765,885)(H,766,912)(H,767,932)(H,768,970)(H,769,981)(H,770,990)(H,771,902)(H,772,971)(H,773,949)(H,774,960)(H,775,991)(H,776,943)(H,777,916)(H,778,953)(H,779,950)(H,780,972)(H,781,992)(H,782,886)(H,783,978)(H,784,993)(H,785,979)(H,786,887)(H,787,917)(H,788,920)(H,789,919)(H,790,918)(H,791,954)(H,792,951)(H,793,952)(H,794,961)(H,795,973)(H,796,982)(H,797,974)(H,847,848)(H,849,850)(H,851,852)(H,853,854)(H,855,856)(H,857,858)(H,859,860)(H,861,862)(H,863,864)(H,865,866)(H,867,868)(H,869,870)(H,871,872)(H,873,874)(H,875,876)(H,877,878)(H,879,880)(H,1004,1005)(H4,657,658,672)(H4,659,660,673)(H4,661,662,674)(H4,663,664,675)(H4,665,666,676)(H4,667,668,677)/t318-,319-,320-,321-,322-,323-,324-,325-,326-,327-,328-,329-,330+,331+,332+,333+,334+,335+,336+,337+,338+,339+,340+,341+,360-,361-,362-,363-,364-,365-,366-,367-,368-,369-,370-,371-,372-,373-,374-,375-,376-,377-,378-,379-,380-,381-,382-,383-,384-,385-,386-,387-,388-,389-,390-,391-,392-,393-,394-,395-,396-,397-,398-,399-,400-,401-,402-,403-,404-,405-,406-,407-,408-,409-,410-,411-,412-,413-,414-,415-,416-,417-,418-,419-,420-,421-,422-,423-,424-,425-,426-,427-,428-,429-,430-,431-,432-,433-,434-,435-,436-,437-,438-,439-,440-,441-,442-,443-,444-,445-,446-,447-,448-,449-,450-,451-,452-,453-,454-,487-,488-,489-,490-,491-,492-,493-,494-,495-,496-,497-,498-,499-,500-,501-,502-,503-,504-,505-,506-,507-/m0/s1

InChIKey

XDODZSAOGHZLCT-HFNJAKBMSA-N