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Substance Name: Lobucavir [USAN:INN]
RN: 127759-89-1
UNII: 8U5PYQ1R2E
InChIKey: GWFOVSGRNGAGDL-FSDSQADBSA-N

Note

  • Inhibits the replication of HIV virus in T cells, monocytes & macrophages in vitro by inhibiting DNA polymerase and viral DNA synthesis.

Molecular Formula

  • C11-H15-N5-O3

Molecular Weight

  • 265.2715
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral Agents
  • Enzyme Inhibitors
  • Nucleic Acid Synthesis Inhibitors
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Names and Synonyms

Name of Substance

  • Lobucavir
  • Lobucavir [USAN:INN]

Synonyms

  • (+)-Cyclobut G
  • 6H-Purin-6-one, 2-amino-9-(2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro, (1R-(1alpha,2beta,3alpha))
  • 9-((1R,2R,3S)-2,3-Bis(hydroxymethyl)cyclobutyl)guanine
  • A-69992
  • BMS 180194
  • BMS-180194
  • C-Oxetanocin-G
  • C-Oxt-G
  • CCRIS 9309
  • DRG-0235
  • Lobucavir
  • SQ 34,514
  • SQ 34514
  • UNII-8U5PYQ1R2E

Systematic Names

  • 6H-Purin-6-one, 2-amino-9-((1R,2R,3S)-2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro-
  • 6H-Purin-6-one, 2-amino-9-(2,3-bis(hydroxymethyl)cyclobutyl)-1,9-dihydro-, (1R-(1alpha,2beta,3alpha))-

Registry Numbers

CAS Registry Number

  • 127759-89-1

FDA UNII

  • 8U5PYQ1R2E

System Generated Number

  • 0127759891

Structure Descriptors

InChI

1S/C11H15N5O3/c12-11-14-9-8(10(19)15-11)13-4-16(9)7-1-5(2-17)6(7)3-18/h4-7,17-18H,1-3H2,(H3,12,14,15,19)/t5-,6-,7-/m1/s1

InChIKey

GWFOVSGRNGAGDL-FSDSQADBSA-N

Smiles

NC1=Nc2c(ncn2[C@@H]3C[C@H](CO)[C@H]3CO)C(=O)N1