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Substance Name: Butylated hydroxytoluene [BAN:NF]
RN: 128-37-0
UNII: 1P9D0Z171K
InChIKey: NLZUEZXRPGMBCV-UHFFFAOYSA-N

Note

  • A di-tert-butyl PHENOL with antioxidant properties.

Molecular Formula

  • C15-H24-O

Molecular Weight

  • 220.3536
 

Classification Codes

Classification Codes

  • Antioxidants
  • Human Data
  • Mutation Data
  • Pharmaceutic Aid (Antioxidant)
  • Protective Agents
  • Reproductive Effect
  • Skin / Eye Irritant
  • Tumor Data

Superlist Classification Codes

  • Overall Carcinogenic Evaluation: Group 3
  • TWA: 2 mg/m3 (inhalable fraction, vapor and aerosol); Not classifiable as a human carcinogen

Names and Synonyms

Name of Substance

  • 2,6-Bis(1,1-dimethylethyl)-4-methylphenol
  • 2,6-Di-t-butyl-p-cresol
  • BHT
  • Butylated hydroxytoluene
  • Butylated hydroxytoluene [BAN:NF]
  • Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-

MeSH Heading

  • Butylated hydroxytoluene

Synonyms

  • 1-Hydroxy-4-methyl-2,6-di-tert-butylbenzene
  • 2,6-Bis(1,1-dimethylethyl)-4-methylphenol
  • 2,6-Di-t-butyl-4-methylphenol
  • 2,6-Di-t-butyl-p-cresol
  • 2,6-Di-terc.butyl-p-kresol
  • 2,6-Di-terc.butyl-p-kresol [Czech]
  • 2,6-Di-tert-butyl-1-hydroxy-4-methylbenzene
  • 2,6-Di-tert-butyl-4-cresol
  • 2,6-Di-tert-butyl-4-hydroxytoluene
  • 2,6-Di-tert-butyl-4-methylhydroxybenzene
  • 2,6-Di-tert-butyl-4-methylphenol
  • 2,6-Di-tert-butyl-p-cresol
  • 2,6-Di-tert-butyl-p-methylphenol
  • 3,5-Di-tert-butyl-4-hydroxytoluene
  • 4-Hydroxy-3,5-di-tert-butyltoluene
  • 4-Methyl-2,6-di-terc. butylfenol
  • 4-Methyl-2,6-di-terc. butylfenol [Czech]
  • 4-Methyl-2,6-di-tert-butylphenol
  • 4-Methyl-2,6-tert-butylphenol
  • Advastab 401
  • Agidol
  • Agidol 1
  • AI3-19683
  • Alkofen BP
  • Antioxidant 264
  • Antioxidant 29
  • Antioxidant 30
  • Antioxidant 4
  • Antioxidant 4K
  • Antioxidant DBPC
  • Antioxidant KB
  • Antioxidant MPJ
  • Antioxidant T 501
  • Antox QT
  • Antrancine 8
  • AO 29
  • AO 4
  • AO 4K
  • AOX 4
  • AOX 4K
  • BAT
  • BHT
  • BHT (food grade)
  • BHT 264
  • BUKS
  • Butylated hydroxytoluene
  • Butylated hydroxytoluol
  • Butylhydroxytoluene
  • Butylohydroksytoluenu
  • Butylohydroksytoluenu [Polish]
  • CAO 1
  • CAO 3
  • Caswell No. 291A
  • Catalin antioxydant 1
  • Catalin cao-3
  • CCRIS 103
  • Chemanox 11
  • Dalpac
  • DBPC
  • DBPC (technical grade)
  • Deenax
  • Di-tert-butyl-p-cresol
  • Di-tert-butyl-p-cresol (VAN)
  • Di-tert-butyl-p-methylphenol
  • Dibunol
  • Dibutylated hydroxytoluene
  • EC 204-881-4
  • EINECS 204-881-4
  • EPA Pesticide Chemical Code 022105
  • FEMA No. 2184
  • HSDB 1147
  • Impruvol
  • Ionol
  • Ionol (antioxidant)
  • Ionol 1
  • Ionol CP
  • Ionol CP-antioxidant
  • Ionole
  • Kerabit
  • NCI-C03598
  • Nocrac 200
  • Nonox TBC
  • NSC 6347
  • o-Di-tert-butyl-p-methylphenol
  • P 21
  • P21
  • Parabar 441
  • Paranox 441
  • Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-
  • Stavox
  • Sumilizer BHT
  • Sustane
  • Sustane BHT
  • Swanox BHT
  • Tenamen 3
  • Tenamene 3
  • Tenox BHT
  • Tonarol
  • Topanol
  • Topanol O
  • Topanol OC
  • Toxolan P
  • UNII-1P9D0Z171K
  • Vanlube PC
  • Vanlube PCX
  • Vianol
  • Vulkanox KB

Systematic Names

  • 2,6-Di-tert-butyl-p-cresol
  • Butylated hydroxytoluene
  • p-Cresol, 2,6-di-tert-butyl-
  • Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-

Superlist Names

  • 2,6-Di-tert-butyl-p-cresol
  • BHT
  • Butylated hydroxytoluene
  • p-Cresol, 2,6-di-tert-butyl-
  • Phenol, 2,6-bis(1,1-dimethylethyl)-4-methyl-

Registry Numbers

CAS Registry Number

  • 128-37-0

FDA UNII

  • 1P9D0Z171K

Other Registry Numbers

  • 102962-45-8
  • 259752-53-9
  • 290348-23-1
  • 36631-28-4
  • 42615-30-5
  • 50356-19-9
  • 50641-99-1
  • 52683-46-2
  • 53571-70-3
  • 58500-82-6
  • 83047-16-9
  • 97123-41-6

System Generated Number

  • 0000128370

Structure Descriptors

InChI

1S/C15H24O/c1-10-8-11(14(2,3)4)13(16)12(9-10)15(5,6)7/h8-9,16H,1-7H3

InChIKey

NLZUEZXRPGMBCV-UHFFFAOYSA-N

Smiles

c1(c(O)c(C(C)(C)C)cc(c1)C)C(C)(C)C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 940mg/kg (940mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: TREMOR

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.
guinea pig LD50 oral 10700mg/kg (10700mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.
mouse LD50 intraperitoneal 138mg/kg (138mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

BLOOD: HEMORRHAGE

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Toxicology and Applied Pharmacology. Vol. 61, Pg. 475, 1981.
mouse LD50 intravenous 180mg/kg (180mg/kg) BEHAVIORAL: SLEEP Journal of Medicinal Chemistry. Vol. 23, Pg. 1350, 1980.
mouse LD50 oral 650mg/kg (650mg/kg) BEHAVIORAL: TREMOR

LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA
Science Reports of the Research Institutes, Tohoku University, Series C: Medicine. Vol. 36(1-4), Pg. 10, 1989.
rabbit LDLo oral 2100mg/kg (2100mg/kg) BEHAVIORAL: TREMOR

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
AMA Archives of Industrial Health. Vol. 11, Pg. 93, 1955.
rat LD50 oral 890mg/kg (890mg/kg)   Neoplasma. Vol. 24, Pg. 253, 1977.
women TDLo oral 80mg/kg (80mg/kg) BEHAVIORAL: COMA

GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: GASTRITIS
New England Journal of Medicine. Vol. 314, Pg. 648, 1986.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 71 deg C   EXP
Boiling Point 265 deg C   EXP
pKa Dissociation Constant 12.23 (none)   EXP
log P (octanol-water) 5.1 (none)   EXP
Water Solubility 0.6 mg/L 25 EXP
Henry's Law Constant 4.12E-06 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.83E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.