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Substance Name: Dihydrostreptomycin [INN:BAN]
RN: 128-46-1
UNII: P2I6R8W6UA
InChIKey: ASXBYYWOLISCLQ-HZYVHMACSA-N

Classification Codes

  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Molecular Formula

  • C21-H41-N7-O12

Molecular Weight

  • 583.5919
 
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Names and Synonyms

Name of Substance

  • Dihydrostreptomycin [INN:BAN]

Synonyms

  • 2,4-Diguanidino-3,5,6-trihydroxycyclohexyl-5-deoxy-2-O-(2-deoxy-2-methylamino-alpha-L-glucopyranosyl)-3-hydroxymethyl-beta-L-lyxo-pentanofuranoside
  • Abiocine
  • DHMS
  • Dihidroestreptomicina
  • Dihidroestreptomicina [INN-Spanish]
  • Dihydrostreptomycin
  • Dihydrostreptomycine
  • Dihydrostreptomycine [INN-French]
  • Dihydrostreptomycinum
  • Dihydrostreptomycinum [INN-Latin]
  • Diidrostreptomicina
  • Diidrostreptomicina [DCIT]
  • DST
  • EINECS 204-888-2
  • Streptomycin, dihydro-
  • UNII-P2I6R8W6UA
  • Vibriomycin

Systematic Names

  • Dihydrostreptomycin
  • Streptamine, O-beta-D-mannopyranosyl-(1-4)-2-deoxy-2-(methylamino)-alpha-L-glucopyranosyl-(1-2)-5-deoxy-O-3-C-(hydroxymethyl)-alpha-L-lyxofuranosyl-(1-4)-N,N'-diamidino-, D-

Superlist Name

  • Dihydrostreptomycin

Registry Numbers

CAS Registry Number

  • 128-46-1

FDA UNII

  • P2I6R8W6UA

System Generated Number

  • 0000128461

Structure Descriptors

InChI

1S/C21H41N7O12/c1-5-21(36,4-30)16(40-17-9(26-2)13(34)10(31)6(3-29)38-17)18(37-5)39-15-8(28-20(24)25)11(32)7(27-19(22)23)12(33)14(15)35/h5-18,26,29-36H,3-4H2,1-2H3,(H4,22,23,27)(H4,24,25,28)/t5-,6-,7+,8-,9-,10-,11+,12-,13-,14+,15+,16-,17-,18-,21+/m0/s1

InChIKey

ASXBYYWOLISCLQ-HZYVHMACSA-N

Smiles

CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@H]2[C@H](O[C@H]3[C@H](O)[C@@H](O)[C@H](NC(=N)N)[C@@H](O)[C@@H]3NC(=N)N)O[C@@H](C)[C@]2(O)CO

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intramuscular 350mg/kg (350mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Archives of Internal Medicine. Vol. 119, Pg. 493, 1967.
mouse LD50 intraperitoneal 533mg/kg (533mg/kg)   "Compounds Available for Fundamental Research, Volume II-6, Antibiotics, A Program of Upjohn Company Research Laboratory." Vol. 2(6), Pg. -, 1971.
mouse LD50 intravenous 200mg/kg (200mg/kg)   "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980Vol. 1, Pg. 96, 1980.
mouse LD50 subcutaneous 1180mg/kg (1180mg/kg)   Antibiotica et Chemotherapia Vol. 11, Pg. 2, 1963.
rat LD50 intravenous 200mg/kg (200mg/kg)   Journal of Bacteriology. Vol. 53, Pg. 205, 1947.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) -7.510 (none)   EST
Atmospheric OH Rate Constant 4.98E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.