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Substance Name: N-Ethylmaleimide
RN: 128-53-0
UNII: O3C74ACM9V
InChIKey: HDFGOPSGAURCEO-UHFFFAOYSA-N

Note

  • A sulfhydryl reagent that is widely used in experimental biochemical studies.

Molecular Formula

  • C6-H7-N-O2

Molecular Weight

  • 125.1263
 

Classification Codes

  • Enzyme Inhibitors
  • Indicators and Reagents
  • Mutation Data
  • Sulfhydryl Reagents
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Names and Synonyms

Name of Substance

  • Ethylmaleimide
  • N-Ethylmaleimide

MeSH Heading

  • Ethylmaleimide

Synonyms

  • 5-21-10-00006 (Beilstein Handbook Reference)
  • AI3-50085
  • BRN 0112448
  • EINECS 204-892-4
  • Ethylmaleimide
  • Maleic acid N-ethylimide
  • Maleimide, N-ethyl-
  • N-Ethylmaleimide
  • NEM
  • NSC 7638
  • RTECS VI8120000
  • UNII-O3C74ACM9V
  • USAF B-121

Systematic Names

  • 1H-Pyrrole-2,5-dione, 1-ethyl-
  • Maleimide, N-ethyl- (8CI)
  • N-Ethylmaleimide

Superlist Name

  • Maleic acid N-ethylimide

Registry Numbers

CAS Registry Number

  • 128-53-0

FDA UNII

  • O3C74ACM9V

System Generated Number

  • 0000128530

Structure Descriptors

InChI

1S/C6H7NO2/c1-2-7-5(8)3-4-6(7)9/h3-4H,2H2,1H3

InChIKey

HDFGOPSGAURCEO-UHFFFAOYSA-N

Smiles

CCN1C(=O)C=CC1=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 skin 500mg/kg (500mg/kg)   National Technical Information Service. Vol. OTS0536969,
mouse LD50 intraperitoneal 5mg/kg (5mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) National Technical Information Service. Vol. OTS0536969,
mouse LD50 oral 25mg/kg (25mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) National Technical Information Service. Vol. OTS0536969,
rat LD50 intraperitoneal 1mg/kg (1mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) National Technical Information Service. Vol. OTS0536969,
rat LD50 oral 25mg/kg (25mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
National Technical Information Service. Vol. OTS0536969,
rat LDLo intracrebral 1669ug/kg (1.669mg/kg)   Journal of Medicinal Chemistry. Vol. 15, Pg. 534, 1972.

Physical Properties

Physical Property Value Units Temp (deg C) Source
Melting Point 45.5 deg C   EXP
log P (octanol-water) 0.580 (none)   EST
Atmospheric OH Rate Constant 2.13E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.