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Substance Name: Raxofelast [INN]
RN: 128232-14-4
UNII: TC0T0O9VYO
InChIKey: QLWBKUUORSULMI-UHFFFAOYSA-N

Note

  • Prodrug of IRFI-005.

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C15-H18-O5

Molecular Weight

  • 278.3022
 
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Names and Synonyms

Name of Substance

  • Raxofelast
  • Raxofelast [INN]

Synonyms

  • (+-)-2,3-Dihydro-5-(acetyloxy)-4,6,7-trimethyl-2-benzofuranacetic acid
  • IRFI 016
  • Raxofelast
  • UNII-TC0T0O9VYO

Systematic Names

  • (+-)-2,3-Dihydro-5-hydroxy-4,6,7-trimethyl-2-benzofuranacetic acid, acetate
  • 2-Benzofuranacetic acid, 2,3-dihydro-5-(acetyloxy)-4,6,7-trimethyl-, (+-)-
  • 2-Benzofuranacetic acid, 5-(acetyloxy)-2,3-dihydro-4,6,7-trimethyl-, (+-)-

Registry Numbers

CAS Registry Number

  • 128232-14-4

FDA UNII

  • TC0T0O9VYO

System Generated Number

  • 0128232144

Structure Descriptors

InChI

1S/C15H18O5/c1-7-8(2)15-12(5-11(20-15)6-13(17)18)9(3)14(7)19-10(4)16/h11H,5-6H2,1-4H3,(H,17,18)

InChIKey

QLWBKUUORSULMI-UHFFFAOYSA-N

Smiles

CC(=O)Oc1c(C)c(C)c2OC(CC(=O)O)Cc2c1C

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 1350mg/kg (1350mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Cardiovascular Drug Reviews. Vol. 15, Pg. 157, 1997.
mouse LD50 oral 7gm/kg (7000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Cardiovascular Drug Reviews. Vol. 15, Pg. 157, 1997.
mouse LDLo intravenous 800mg/kg (800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Cardiovascular Drug Reviews. Vol. 15, Pg. 157, 1997.
rat LD50 intraperitoneal 1200mg/kg (1200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Cardiovascular Drug Reviews. Vol. 15, Pg. 157, 1997.
rat LD50 intravenous 650mg/kg (650mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Cardiovascular Drug Reviews. Vol. 15, Pg. 157, 1997.