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Substance Name: Hydroxypropyl betadex [NF]
RN: 128446-35-5

Note

  • Derivative of beta-cyclodextrin that is used as an excipient for steroid drugs and as a lipid chelator.

Molecular Formula

  • C42-H70-O35.C2-H5-O

Molecular Weight

  • 1180.0405
 

Classification Codes

  • Excipients
  • Pharmaceutic Aids
  • Pharmaceutical Vehicles
  • Treatment of Niemann-Pick Type C Disease
  • TSCA Flag PMN (a Commenced PMN (Premanufacture Notice) Substance)
  • TSCA UVCB
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Links to Resources

NLM Resources (File Locators)

Regulatory Agencies (Superlist Locators)

Other Resources (Internet Locators)

Names and Synonyms

Name of Substance

  • 2-Hydroxypropyl-beta-cyclodextrin
  • Adrabetadex [USAN]
  • Hydroxypropyl betadex [NF]

MeSH Heading

  • 2-Hydroxypropyl-beta-cyclodextrin

Synonyms

  • 2-Hydroxypropyl-beta-cyclodextrin
  • Adrabetadex
  • beta-Hydroxypropylcyclodextrin
  • HPB
  • Hydroxypropyl beta cyclodextrin
  • Hydroxypropyl betadex
  • UNII-1I96OHX6EK
  • UNII-8W6Q67R6NX
  • VTS-270

Systematic Names

  • beta-Cyclodextrin, 2-hydroxypropyl ether
  • beta-Cyclodextrin, 2-hydroxypropyl ethers

Registry Numbers

CAS Registry Number

  • 128446-35-5

FDA UNIIs

  • 1I96OHX6EK
  • 8W6Q67R6NX

Other Registry Number

  • 94035-02-6

System Generated Number

  • 0128446355

Structure Descriptors

Smiles

[*]CCO.OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3CO)O[C@H]4[C@H](O)[C@@H](O)[C@H](O[C@@H]4CO)O[C@H]5[C@H](O)[C@@H](O)[C@H](O[C@@H]5CO)O[C@H]6[C@H](O)[C@@H](O)[C@H](O[C@@H]6CO)O[C@H]7[C@H](O)[C@@H](O)[C@H](O[C@@H]7CO)O[C@H]8[C@H](O)[C@@H](O)[C@H](O[C@@H]8CO)O[C@H]1[C@H](O)[C@H]2O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD intravenous > 5gm/kg (5000mg/kg)   Journal of Pharmaceutical Sciences. Vol. 84, Pg. 1223, 1995.