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Substance Name: Romidepsin [USAN:INN]
RN: 128517-07-7
UNII: CX3T89XQBK
InChIKey: OHRURASPPZQGQM-GCCNXGTGSA-N
Note
- A bicyclic depsipeptide and a potent histone deacetylase inhibitor from Chromobacterium violaceum.
Molecular Formula
- C24-H36-N4-O6-S2
Molecular Weight
- 540.7024
Classification Codes
- Antibiotics, Antineoplastic
- Antineoplastic Agents
- Antitumor/Anticancer Drug
- Drug / Therapeutic Agent
- Enzyme Inhibitors
- Histone Deacetylase Inhibitors
- Natural Product
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Names and Synonyms
Name of Substance
- Romidepsin
- Romidepsin [USAN:INN]
Synonyms
- Antibiotic FR 901228
- Chromadax
- Cyclo((2Z)-2-amino-2-butenoyl-L-valyl-(3S,4E)-3-hydroxy-7-mercapto-4-heptenoyl-D-valyl-D-cysteinyl), cyclic (3->5)-disulfide
- FK 228
- FK228
- FR 901228
- FR-901228
- FR901228
- Istodax
- NSC 630176
- Romidepsin
- UNII-CX3T89XQBK
Systematic Names
- (1S,4S,7Z,10S,16E,21R)-7-Ethylidene-4,21-bis(1-methylethyl)-2-oxa-12,13-dithia-5,8,20,23-tetraazabicyclo(8.7.6)tricos-16-ene-3,6,9,19,22-pentone
- L-Valine, N-((3S,4E)-3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(2Z)-2-amino-2-butenoxyl-, (4-1)-lactone, cyclic (1-2)-disulfide
- L-Valine, N-(3-hydroxy-7-mercapto-1-oxo-4-heptenyl)-D-valyl-D-cysteinyl-(Z)-2,3-didehydro-2-aminobutanoyl-, xi-lactone, cyclic (1-2)-disulfide, (S-(E))-
Registry Numbers
CAS Registry Number
- 128517-07-7
FDA UNII
- CX3T89XQBK
System Generated Number
- 0128517077
Structure Descriptors
InChI
InChI=1S/C24H36N4O6S2/c1-6-16-21(30)28-20(14(4)5)24(33)34-15-9-7-8-10-35-36-12-17(22(31)25-16)26-23(32)19(13(2)3)27-18(29)11-15/h6-7,9,13-15,17,19-20H,8,10-12H2,1-5H3,(H,25,31)(H,26,32)(H,27,29)(H,28,30)/b9-7+,16-6-/t15-,17-,19-,20+/m1/s1InChIKey
OHRURASPPZQGQM-GCCNXGTGSA-NSmiles
C\C=C\1/NC(=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | intraperitoneal | 6400ug/kg (6.4mg/kg) | Journal of Antibiotics. Vol. 47, Pg. 301, 1994. | |
mouse | LD50 | intravenous | 10mg/kg (10mg/kg) | Journal of Antibiotics. Vol. 47, Pg. 301, 1994. |