Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Warfarin sodium [USP]
RN: 129-06-6
UNII: 6153CWM0CL
InChIKey: KYITYFHKDODNCQ-UHFFFAOYSA-M

Note

  • An anticoagulant that acts by inhibiting the synthesis of vitamin K-dependent coagulation factors. Warfarin is indicated for the prophylaxis and/or treatment of venous thrombosis and its extension, pulmonary embolism, and atrial fibrillation with embolization. It is also used as an adjunct in the prophylaxis of systemic embolism after myocardial infarction. Warfarin is also used as a rodenticide.

Molecular Formulas

  • C19-H15-Na-O4
  • C19-H15-O4.Na
  • C19-H16-O4.Na

Molecular Weight

  • 330.3135
 

Classification Codes

Classification Codes

  • Anticoagulant
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Reproductive Effect

Superlist Classification Code

  • Threshold Planning Quantity (TPQ) = 100/10000 lb

Names and Synonyms

Name of Substance

  • Warfarin sodium [USP]

Synonyms

  • (+-)-Warfarin sodium
  • 3-(alpha-Acetonylbenzyl)-4-hydroxycoumarin sodium salt
  • Aldocumar
  • Athrombin
  • Caswell No. 903A
  • Coumadan Sodico
  • Coumadin
  • Coumadin sodium
  • Coumadine
  • Coumafene sodium
  • Dicusat
  • EINECS 204-929-4
  • EPA Pesticide Chemical Code 086003
  • Jantoven
  • Marevam
  • Marevan
  • Orfarin
  • Panwarfin
  • Prothromadin
  • Ratsul soluble
  • Simarc
  • Sodium coumadin
  • Sodium warfarin
  • Sodium, ((3-(alpha-acetonylbenzyl)-2-oxo-2H-1-benzopyran-4-yl)oxy)-
  • Tintorane
  • UNII-6153CWM0CL
  • UniWarfin
  • Varfine
  • Waran
  • Warcoumin
  • Warfarin sodium
  • Warfarin, sodium deriv.
  • Warfarin, sodium salt
  • Warfilone
  • Zoocoumarin sodium salt

Systematic Names

  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, sodium salt
  • 2H-1-Benzopyran-2-one, 4-hydroxy-3-(3-oxo-1-phenylbutyl)-, sodium salt (1:1)
  • Coumarin, 3-(alpha-acetonylbenzyl)-4-hydroxy-, sodium salt
  • Warfarin sodium

Superlist Names

  • Sodium warfarin
  • Warfarin sodium

Registry Numbers

CAS Registry Number

  • 129-06-6

FDA UNII

  • 6153CWM0CL

Other Registry Numbers

  • 12795-55-0
  • 51821-81-9
  • 859043-62-2

System Generated Number

  • 0000129066

Molecular Formulas

Molecular Formulas

  • C19-H15-Na-O4
  • C19-H15-O4.Na
  • C19-H16-O4.Na

Molecular Formula Fragments

  • C19-H15-O4
  • C19-H16-O4
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C19H16O4.Na/c1-12(20)11-15(13-7-3-2-4-8-13)17-18(21)14-9-5-6-10-16(14)23-19(17)22;/h2-10,15,21H,11H2,1H3;/q;+1/p-1

InChIKey

KYITYFHKDODNCQ-UHFFFAOYSA-M

Smiles

CC(=O)CC(c1ccccc1)c2c(c3ccccc3oc2=O)[O-].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
chicken LD50 intravenous 200mg/kg (200mg/kg) BLOOD: HEMORRHAGE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
child TDLo oral 4mg/kg (4mg/kg) BLOOD: CHANGES IN CELL COUNT (UNSPECIFIED) American Journal of Diseases of Children. Vol. 147, Pg. 609, 1993.
dog LD50 intravenous 200mg/kg (200mg/kg) BLOOD: HEMORRHAGE

SKIN AND APPENDAGES (SKIN): HAIR: OTHER

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
dog LD50 oral 200mg/kg (200mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
guinea pig LD50 oral 182mg/kg (182mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
guinea pig LDLo intravenous 543mg/kg (543mg/kg)   Therapie. Vol. 18, Pg. 921, 1963.
mouse LD50 intravenous 160mg/kg (160mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 123, 1969.
mouse LD50 oral 374mg/kg (374mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
rabbit LD50 intravenous 100mg/kg (100mg/kg) BLOOD: HEMORRHAGE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
rabbit LD50 oral 800mg/kg (800mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 42, Pg. 379, 1953.
rat LD50 intravenous 25mg/kg (25mg/kg)   "Handbook of Analytical Toxicology," Sunshine, I., ed., Cleveland, OH, Chemical Rubber Co., 1969Vol. -, Pg. 123, 1969.
rat LD50 oral 8700ug/kg (8.7mg/kg) BLOOD: HEMORRHAGE Pharmacological Research Communications. Vol. 10, Pg. 445, 1978.
women TDLo oral 300ug/kg/2D (0.3mg/kg) SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE" Archives of Dermatology. Vol. 116, Pg. 444, 1980.