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Substance Name: Merbromin [INN:NF]
RN: 129-16-8
UNII: M0T18YH28D
InChIKey: JXQGSRKVFQSVTR-UHFFFAOYSA-K

Note

  • A once-popular mercury containing topical antiseptic.

Classification Codes

  • Drug / Therapeutic Agent
  • Mutation Data

Molecular Formulas

  • C20-H10-Br2-Hg-O6.2Na
  • C20-H8-Br2-Hg-Na2-O6
  • C20-H8-Br2-Hg-O6.2Na

Molecular Weight

  • 750.6552
 
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Names and Synonyms

Name of Substance

  • Merbromin
  • Merbromin [INN:NF]

MeSH Headings

  • Merbromin
  • Mercurochrome

Synonyms

  • 2,7-Dibromo-4-hydroxymercurifluoresceine disodium salt
  • Asceptichrome
  • Aseptichrome
  • Chromargyre
  • Disodium 2',7'-dibromo-4'-(hydroxymercury)fluorescein
  • Disodium 2,7-dibrom-4-hydroxy-mercuri-fluorescein
  • DOMF
  • EINECS 204-933-6
  • Flavurol
  • Fluorochrome
  • Gallochrome
  • Gynochrome
  • HSDB 6800
  • Merbromin
  • Merbromina
  • Merbromina [INN-Spanish]
  • Merbromine
  • Merbromine [INN-French]
  • Merbrominum
  • Merbrominum [INN-Latin]
  • Mercuranine
  • Mercurochrome
  • Mercurochrome-220 soluble
  • Mercurochromum
  • Mercurocol
  • Mercurome
  • Mercurophage
  • Planochrome
  • UNII-M0T18YH28D

Systematic Names

  • Disodium salt of 2,7-dibromo-4-hydroxymercurifluoresceine
  • Fluorescein, 2',7'-dibromo-4'-(hydroxymercurio)-, disodium salt
  • Merbromin
  • Mercury, (2',7'-dibromo-3',6'-dihydroxy-3-oxospiro(isobenzofuran-1(3H),9'-(9H)xanthen)-4'-yl)hydroxy-, disodium salt

Registry Numbers

CAS Registry Number

  • 129-16-8

FDA UNII

  • M0T18YH28D

System Generated Number

  • 0000129168

Molecular Formulas

Molecular Formulas

  • C20-H10-Br2-Hg-O6.2Na
  • C20-H8-Br2-Hg-Na2-O6
  • C20-H8-Br2-Hg-O6.2Na

Molecular Formula Fragments

  • C20-H10-Br2-Hg-O6
  • C20-H8-Br2-Hg-O6
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C20H9Br2O5.Hg.2Na.H2O/c21-13-5-11-17(7-15(13)23)26-18-8-16(24)14(22)6-12(18)20(11)10-4-2-1-3-9(10)19(25)27-20;;;;/h1-7,23-24H;;;;1H2/q;3*+1;/p-3

InChIKey

JXQGSRKVFQSVTR-UHFFFAOYSA-K

Smiles

c1ccc2c(c1)C(=O)OC23c4cc(c(cc4Oc5c3cc(c(c5[Hg]O)[O-])Br)[O-])Br.[Na+].[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intravenous 50mg/kg (50mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 645, 1931.
mouse LDLo intraperitoneal 200mg/kg (200mg/kg)   Journal of Pharmacology and Experimental Therapeutics. Vol. 43, Pg. 71, 1931.
mouse LDLo subcutaneous 20mg/kg (20mg/kg)   Monatsschrift fuer Ohrenheilkunde und Laryngo-Rhinologie. Vol. 73, Pg. 751, 1939.
rabbit LDLo intravenous 15mg/kg (15mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: MUSCLE WEAKNESS
Journal of Pharmacology and Experimental Therapeutics. Vol. 35, Pg. 343, 1929.
women TDLo oral 10uL/kg (0.01mL/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

GASTROINTESTINAL: OTHER CHANGES
Journal of Toxicology, Clinical Toxicology. Vol. 35, Pg. 657, 1997.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.410 (none)   EST
Water Solubility 2.00E+04 mg/L   EXP
Atmospheric OH Rate Constant 1.96E-10 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.