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Substance Name: Chlorcyclizine dihydrochloride
RN: 129-71-5
UNII: 61Y56T95YL
InChIKey: FLEBQACKYGHXTR-UHFFFAOYSA-N

Classification Code

  • Drug / Therapeutic Agent

Molecular Formula

  • C18-H21-Cl-N2.2Cl-H

Molecular Weight

  • 373.7527
 
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Names and Synonyms

Results Name

  • Chlorcyclizine dihydrochloride

Name of Substance

  • Chlorcyclizine dihydrochloride

Synonyms

  • 1-(4-Chlorobenzhydryl)-4-methylpiperazine dihydrochloride
  • 1-(p-Chloro-alpha-phenylbenzyl)-4-methyl-piperazine dihydrochloride
  • AH 289
  • Chlorcyclizine dihydrochloride
  • Chlorcyclizine HCl
  • Di-paralene
  • Histantine dihydrochloride
  • N-Methyl-N'-(4-chlorobenzhydryl)piperazine dihydrochloride
  • Perazil dihydrochloride
  • Trihistan
  • UNII-61Y56T95YL

Systematic Name

  • Piperazine, 1-(p-chloro-alpha-phenylbenzyl)-4-methyl-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 129-71-5

FDA UNII

  • 61Y56T95YL

System Generated Number

  • 0000129715

Molecular Formulas

Molecular Formula

  • C18-H21-Cl-N2.2Cl-H

Molecular Formula Fragments

  • C18-H21-Cl-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C18H21ClN2.2ClH/c1-20-11-13-21(14-12-20)18(15-5-3-2-4-6-15)16-7-9-17(19)10-8-16;;/h2-10,18H,11-14H2,1H3;2*1H

InChIKey

FLEBQACKYGHXTR-UHFFFAOYSA-N

Smiles

CN1CCN(CC1)C(c2ccccc2)c3ccc(cc3)Cl.Cl.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LD50 intraperitoneal 75mg/kg (75mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 378, 1949.
dog LDLo intraperitoneal 100mg/kg (100mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 378, 1949.
guinea pig LD50 intraperitoneal 100mg/kg (100mg/kg) PERIPHERAL NERVE AND SENSATION: LOCAL ANESTHETIC Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 378, 1949.
mouse LD50 intraperitoneal 137mg/kg (137mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BEHAVIORAL: TREMOR

BEHAVIORAL: EXCITEMENT
Journal of Pharmacology and Experimental Therapeutics. Vol. 96, Pg. 388, 1949.
mouse LD50 intravenous 35mg/kg (35mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 378, 1949.
mouse LDLo oral 150mg/kg (150mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 378, 1949.
mouse LDLo subcutaneous 150mg/kg (150mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 378, 1949.
rat LD50 intraperitoneal 100mg/kg (100mg/kg)   Archives Internationales de Pharmacodynamie et de Therapie. Vol. 80, Pg. 378, 1949.