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Substance Name: Buclizine hydrochloride [USAN]
RN: 129-74-8
UNII: 58FQD093NU
InChIKey: SDBHDSZKNVDKNU-UHFFFAOYSA-N

Note

  • A histamine H1 antagonist used in the treatment of motion sickness, vertigo, and nausea during pregnancy and radiation sickness.

Molecular Formula

  • C28-H33-Cl-N2.2Cl-H

Molecular Weight

  • 505.957
 

Classification Codes

  • Antinauseant
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Buclizine dihydrochloride
  • Buclizine hydrochloride [USAN]

Synonyms

  • 1-(p-Chlorobenzhydryl)-4-(p-t-butylbenzyl)diethylenediamine dihydrochloride
  • 1-(p-tert-Butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)piperazine dihydrochloride
  • 1-(p-tert-Butylbenzyl)-4-(p-chlorodiphenylmethyl)piperazine dihydrochloride
  • 1-p-Chlorobenzhydryl-4-p-(t)-butylbenzylpiperazine dihydrochloride
  • A 7668
  • Aphilan R
  • Bucladin
  • Bucladin S
  • Bucladin-S
  • Buclina
  • Buclizine dihydrochloride
  • Buclizine HCl
  • Buclizine hydrochloride
  • EINECS 204-962-4
  • Histabutyzine dihydrochloride
  • Histabutyzine hydrochloride
  • Longifene
  • NSC 25141
  • Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, dihydrochloride
  • Postafeno
  • Softran
  • UCB 4445
  • UNII-58FQD093NU
  • Vibazine hydrochloride

Systematic Names

  • Buclizine dihydrochloride
  • Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, dihydrochloride
  • Piperazine, 1-((4-chlorophenyl)phenylmethyl)-4-((4-(1,1-dimethylethyl)phenyl)methyl)-, hydrochloride (1:2)
  • Piperazine, 1-(p-tert-butylbenzyl)-4-(p-chloro-alpha-phenylbenzyl)-, dihydrochloride

Registry Numbers

CAS Registry Number

  • 129-74-8

FDA UNII

  • 58FQD093NU

Related Registry Number

  • 82-95-1 (Parent)

System Generated Number

  • 0000129748

Molecular Formulas

Molecular Formula

  • C28-H33-Cl-N2.2Cl-H

Molecular Formula Fragments

  • C28-H33-Cl-N2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C28H33ClN2.2ClH/c1-28(2,3)25-13-9-22(10-14-25)21-30-17-19-31(20-18-30)27(23-7-5-4-6-8-23)24-11-15-26(29)16-12-24;;/h4-16,27H,17-21H2,1-3H3;2*1H

InChIKey

SDBHDSZKNVDKNU-UHFFFAOYSA-N

Smiles

Cl.Cl.N1([C@@H](c2ccc(Cl)cc2)c2ccccc2)CCN(Cc2ccc(C(C)(C)C)cc2)CC1

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 430mg/kg (430mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954.
mouse LD50 oral 2100mg/kg (2100mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES
Journal of the American Pharmaceutical Association, Scientific Edition. Vol. 43, Pg. 653, 1954.