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Substance Name: Iodoantipyrine
RN: 129-81-7
UNII: V30V6H1QX4
InChIKey: ZZOBLCHCPLOXCE-UHFFFAOYSA-N

Note

  • An analgesic and antipyretic that has been given by mouth and as ear drops. Antipyrine is often used in testing the effects of other drugs or diseases on drug-metabolizing enzymes in the liver. (From Martindale, The Extra Pharmacopoeia, 30th ed, p29)

Molecular Formula

  • C11-H11-I-N2-O

Molecular Weight

  • 314.1209
 

Classification Codes

  • Analgesics
  • Analgesics, Non-Narcotic
  • Anti-Infective Agents
  • Anti-Inflammatory Agents
  • Anti-Inflammatory Agents, Non-Steroidal
  • Antirheumatic Agents
  • Antiviral Agents
  • Peripheral Nervous System Agents
  • Sensory System Agents
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Names and Synonyms

Name of Substance

  • Iodoantipyrine

Synonyms

  • 1,2-Dihydro-4-iod-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on
  • 1,2-Dihydro-4-iod-1,5-dimethyl-2-phenyl-3H-pyrazol-3-on [IUPAC]
  • 1,2-Dihydro-4-iodo-1,5-dimethyl-2-phenyl-3H-pyrazol-3-one
  • 4-Iod-2,3-dimethyl-1-phenyl-3-pyrazolin-5-on
  • 4-Iodoantipyrine
  • Antipyrine iodide
  • Arthripur
  • EINECS 204-966-6
  • Iodoantipyrine
  • Iodophenazone
  • Iodopyrine
  • Jodantipyrine
  • Jodopyrine
  • UNII-V30V6H1QX4

Systematic Names

  • 1,2-Dihydro-4-iodo-1,5-dimethyl-2-phenyl-2H-pyrazol-3-one
  • 3H-Pyrazol-3-one, 1,2-dihydro-4-iodo-1,5-dimethyl-2-phenyl-
  • 4-Iodo-2,3-dimethyl-1-phenyl-3-pyrazolin-5-one
  • Antipyrine, 4-iodo- (6CI,7CI,8CI)

Registry Numbers

CAS Registry Number

  • 129-81-7

FDA UNII

  • V30V6H1QX4

System Generated Number

  • 0000129817

Structure Descriptors

InChI

1S/C11H11IN2O/c1-8-10(12)11(15)14(13(8)2)9-6-4-3-5-7-9/h3-7H,1-2H3

InChIKey

ZZOBLCHCPLOXCE-UHFFFAOYSA-N

Smiles

Cc1c(c(=O)n(n1C)c2ccccc2)I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 oral 1600mg/kg (1600mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. Vol. 61(2), Pg. 57, 1998.
rat LD50 intraperitoneal 1720mg/kg (1720mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. Vol. 61(2), Pg. 57, 1998.
rat LD50 oral 2060mg/kg (2060mg/kg) GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA"

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Eksperimental'naya i Klinicheskaya Farmakologiya. Experimental and Clinical Pharmacology. Vol. 61(2), Pg. 57, 1998.

Physical Properties

Physical Property Value Units Temp (deg C) Source
log P (octanol-water) 1.27 (none)   EXP
Water Solubility 800 mg/L 17 EXP
Vapor Pressure 7.03E-07 mm Hg 25 EST
Henry's Law Constant 8.37E-11 atm-m3/mole 25 EST
Atmospheric OH Rate Constant 1.98E-11 cm3/molecule-sec 25 EST

Physical property data is provided to ChemIDplus by SRC, Inc.