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Substance Name: Perospirone hydrochloride
RN: 129273-38-7
UNII: T884I76TMN
InChIKey: HIZFAPMOZFYELI-GNXQHMNLSA-N

Classification Codes

  • Antipsychotic Agents
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Drug / Therapeutic Agent
  • Psychotropic Drugs
  • Tranquilizing Agents

Molecular Formula

  • C23-H30-N4-O2-S.Cl-H

Molecular Weight

  • 463.0429
 
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Names and Synonyms

Results Name

  • Perospirone hydrochloride

Name of Substance

  • Perospirone

Synonyms

  • Perospirone hydrochloride
  • SM 9018
  • SM-9018
  • UNII-T884I76TMN

Systematic Names

  • 1H-Isoindole-1,3(2H)-dione, 2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)hexahydro-, monohydrochloride, (3aR,7aS)-rel-
  • 1H-Isoindole-1,3(2H)-dione, 2-(4-(4-(1,2-benzisothiazol-3-yl)-1-piperazinyl)butyl)hexahydro-, monohydrochloride, cis-

Registry Numbers

CAS Registry Number

  • 129273-38-7

FDA UNII

  • T884I76TMN

System Generated Number

  • 0129273387

Molecular Formulas

Molecular Formula

  • C23-H30-N4-O2-S.Cl-H

Molecular Formula Fragments

  • C23-H30-N4-O2-S
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C23H30N4O2S.ClH/c28-22-17-7-1-2-8-18(17)23(29)27(22)12-6-5-11-25-13-15-26(16-14-25)21-19-9-3-4-10-20(19)30-24-21;/h3-4,9-10,17-18H,1-2,5-8,11-16H2;1H/t17-,18+;

InChIKey

HIZFAPMOZFYELI-GNXQHMNLSA-N

Smiles

c1ccc2c(c1)c(ns2)N3CCN(CC3)CCCCN4C(=O)[C@@H]5CCCC[C@@H]5C4=O.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
monkey LDLo oral 2gm/kg (2000mg/kg) KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"

LIVER: FATTY LIVER DEGERATION
Kiso to Rinsho. Clinical Report. Vol. 31, Pg. 201, 1997.
mouse LD50 oral 660mg/kg (660mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 31, Pg. 177, 1997.
rat LD50 intravenous 33mg/kg (33mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

SENSE ORGANS AND SPECIAL SENSES: LACRIMATION: EYE

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 31, Pg. 177, 1997.
rat LD50 oral 870mg/kg (870mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

SKIN AND APPENDAGES (SKIN): HAIR: OTHER
Kiso to Rinsho. Clinical Report. Vol. 31, Pg. 177, 1997.