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Substance Name: Alendronate sodium
RN: 129318-43-0
UNII: 4988K7X26P
InChIKey: CAKRAHQRJGUPIG-UHFFFAOYSA-M

Molecular Formula

  • C4-H13-N-O7-P2.Na

Molecular Weight

  • 271.0768
 
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Names and Synonyms

Results Name

  • Alendronate sodium

Name of Substance

  • Alendronate sodium anhydrous

Synonyms

  • (4-Amino-1-hydroxybutylidene)bisphosphonic acid monosodium salt
  • Alend
  • Alendronate sodium
  • Binosto
  • Fosamac
  • Fosamax
  • Indrol
  • MK 217
  • Monosodium alendronate
  • NeoBon
  • Onclast
  • Osteovan
  • UNII-4988K7X26P

Systematic Name

  • Phosphonic acid, (4-amino-1-hydroxybutylidene)bis-, monosodium salt

Mixture Name

  • Fosamax Plus D

Registry Numbers

CAS Registry Number

  • 129318-43-0

FDA UNII

  • 4988K7X26P

System Generated Number

  • 0129318430

Molecular Formulas

Molecular Formula

  • C4-H13-N-O7-P2.Na

Molecular Formula Fragments

  • C4-H13-N-O7-P2
  • COMPONENT
  • Na

Structure Descriptors

InChI

1S/C4H13NO7P2.Na/c5-3-1-2-4(6,13(7,8)9)14(10,11)12;/h6H,1-3,5H2,(H2,7,8,9)(H2,10,11,12);/q;+1/p-1

InChIKey

CAKRAHQRJGUPIG-UHFFFAOYSA-M

Smiles

C(CC(O)(P(=O)(O)O)P(=O)(O)[O-])CN.[Na+]

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 200mg/kg (200mg/kg)   International Journal of Clinical Practice, Supplement. Vol. 101, Pg. 3, 1999.
dog LDLo intravenous 10mg/kg (10mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3229, 1994.
mouse LD50 oral 966mg/kg (966mg/kg)   International Journal of Clinical Practice, Supplement. Vol. 101, Pg. 3, 1999.
rat LD50 oral 552mg/kg (552mg/kg) GASTROINTESTINAL: NECROTIC GHANGES International Journal of Clinical Practice, Supplement. Vol. 101, Pg. 3, 1999.
rat LDLo intravenous 30mg/kg (30mg/kg) GASTROINTESTINAL: ULCERATION OR BLEEDING FROM STOMACH

SENSE ORGANS AND SPECIAL SENSES: PTOSIS: EYE

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Kiso to Rinsho. Clinical Report. Vol. 28, Pg. 3229, 1994.
women TDLo oral 700ug/kg/7D-I (0.7mg/kg) GASTROINTESTINAL: OTHER CHANGES

GASTROINTESTINAL: CHANGE IN STRUCTURE OR FUNCTION OF ESOPHAGUS
American Journal of Gastroenterology. Vol. 90, Pg. 1889, 1995.