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Substance Name: Fulvestrant [USAN:USP:INN:BAN]
RN: 129453-61-8
UNII: 22X328QOC4
InChIKey: VWUXBMIQPBEWFH-WCCTWKNTSA-N

Notes

  • An estradiol derivative and estrogen receptor antagonist that is used for the treatment of estrogen receptor-positive, locally advanced or metastatic breast cancer.
  • NCI: A synthetic estrogen receptor antagonist. Unlike tamoxifen (which has partial agonist effects) and the aromatase inhibitors (which reduce the estrogen available to tumor cells), fulvestrant binds competitively to estrogen receptors in breast cancer cells, resulting in estrogen receptor deformation and decreased estrogen binding. In vitro studies indicate that fulvestrant reversibly inhibits the growth of tamoxifen-resistant, estrogen-sensitive, human breast cancer cell lines. Check for active clinical trials or closed clinical trials using this agent. (NCI Thesaurus)

Molecular Formula

  • C32-H47-F5-O3-S

Molecular Weight

  • 606.7763
 

Classification Codes

  • Antineoplastic Agents
  • Antineoplastic Agents, Hormonal
  • Estrogen Antagonists
  • Estrogen Receptor Antagonists
  • Estrogen Receptor Modulators
  • Hormone Antagonists
  • Hormones, Hormone Substitutes, and Hormone Antagonists
  • Treatment of Breast Cancer (Antiestrogen)

Names and Synonyms

Name of Substance

  • Fulvestrant
  • Fulvestrant [USAN:USP:INN:BAN]

MeSH Heading

  • Fulvestrant

Synonyms

  • 7alpha-(9-((4,4,5,5,5-Pentafluoropentyl)sulfinyl)nonyl)estra-1,3,5(10)-triene-3,17beta-diol
  • CCRIS 8741
  • Faslodex
  • Fulvestrant
  • HSDB 7658
  • ICI 182,780
  • ICI 182780
  • ICI-182780
  • UNII-22X328QOC4
  • ZD9238
  • ZM 182780
  • ZM-182780

Systematic Name

  • Estra-1,3,5(10)-triene-3,17-diol, 7-(9-((4,4,5,5,5-pentafluoropentyl)sulfinyl)nonyl)-, (7alpha,17beta)-

Registry Numbers

CAS Registry Number

  • 129453-61-8

FDA UNII

  • 22X328QOC4

System Generated Number

  • 0129453618

Structure Descriptors

InChI

InChI=1S/C32H47F5O3S/c1-30-17-15-26-25-12-11-24(38)21-23(25)20-22(29(26)27(30)13-14-28(30)39)10-7-5-3-2-4-6-8-18-41(40)19-9-16-31(33,34)32(35,36)37/h11-12,21-22,26-29,38-39H,2-10,13-20H2,1H3/t22-,26-,27+,28+,29-,30+,41?/m1/s1

InChIKey

VWUXBMIQPBEWFH-WCCTWKNTSA-N

Smiles

C[C@]12CC[C@H]3[C@@H]([C@H](CCCCCCCCCS(=O)CCCC(F)(F)C(F)(F)F)Cc4cc(O)ccc34)[C@@H]1CC[C@@H]2O