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Substance Name: Nevirapine [USAN:USP:INN:BAN]
RN: 129618-40-2
UNII: 99DK7FVK1H
InChIKey: NQDJXKOVJZTUJA-UHFFFAOYSA-N

Note

  • A potent, non-nucleoside reverse transcriptase inhibitor used in combination with nucleoside analogues for treatment of HIV INFECTIONS and AIDS.

Molecular Formula

  • C15-H14-N4-O

Molecular Weight

  • 266.3026
 

Classification Codes

  • Anti-HIV Agents
  • Anti-Infective Agents
  • Anti-Retroviral Agents
  • Antiviral
  • Antiviral Agents
  • Cytochrome P-450 CYP3A Inducers
  • Enzyme Inhibitors
  • Nucleic Acid Synthesis Inhibitors
  • Reverse Transcriptase Inhibitors

Names and Synonyms

Name of Substance

  • Nevirapine
  • Nevirapine [USAN:USP:INN:BAN]

MeSH Heading

  • Nevirapine

Synonyms

  • 11-Cyclopropyl-5,11-dihydro-4-methyl-6H-dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one
  • BI-RG-587
  • BIRG 0587
  • BIRG587
  • HSDB 7164
  • Nevirapine
  • NSC 641530
  • NVP
  • UNII-99DK7FVK1H
  • Viramune
  • Viramune XR

Systematic Name

  • 6H-Dipyrido(3,2-b:2',3'-e)(1,4)diazepin-6-one, 11-cyclopropyl-5,11-dihydro-4-methyl-

Registry Numbers

CAS Registry Number

  • 129618-40-2

FDA UNII

  • 99DK7FVK1H

System Generated Number

  • 0129618402

Structure Descriptors

InChI

1S/C15H14N4O/c1-9-6-8-17-14-12(9)18-15(20)11-3-2-7-16-13(11)19(14)10-4-5-10/h2-3,6-8,10H,4-5H2,1H3,(H,18,20)

InChIKey

NQDJXKOVJZTUJA-UHFFFAOYSA-N

Smiles

Cc1ccnc2c1NC(=O)c3cccnc3N2C4CC4

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD oral > 3200mg/kg (3200mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 41, Pg. 2209, 1999.
rat LDLo oral 400mg/kg (400mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 41, Pg. 2209, 1999.