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Substance Name: Bizelesin [USAN:INN]
RN: 129655-21-6
UNII: L0O9OBI87E
InChIKey: FONKWHRXTPJODV-DNQXCXABSA-N

Note

  • An analog of the cyclopropylpyrroloindole antitumor antibiotic CC-1065.

Molecular Formula

  • C43-H36-Cl2-N8-O5

Molecular Weight

  • 815.714
 

Classification Codes

  • Alkylating Agents
  • Antineoplastic
  • Antineoplastic Agents
  • Antineoplastic Agents, Alkylating
  • Cross-Linking Reagents
  • Indicators and Reagents
  • Noxae
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Names and Synonyms

Name of Substance

  • Bizelesin
  • Bizelesin [USAN:INN]

Synonyms

  • 1,3-Bis(2-(((S)-1-(chloromethyl)-1,6-dihydro-5-hydroxy-8-methylbenzo(1,2-b:4,3-b')dipyrrol-3(2H)-yl)carbonyl)indol-5-yl)urea
  • Benzo(1,2-b:4,3-b')dipyrrol-4-ol, 6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*))-
  • Bizelesin
  • U-77,779
  • U-77779
  • UNII-L0O9OBI87E

Systematic Name

  • Benzo(1,2-b:4,3-b')dipyrrol-4-ol, 6,6'-(carbonylbis(imino-1H-indole-5,2-diylcarbonyl))bis(8-(chloromethyl)-3,6,7,8-tetrahydro-1-methyl-, (S-(R*,R*))-

Registry Numbers

CAS Registry Number

  • 129655-21-6

FDA UNII

  • L0O9OBI87E

System Generated Number

  • 0129655216

Structure Descriptors

InChI

1S/C43H36Cl2N8O5/c1-19-15-46-39-33(54)11-31-37(35(19)39)23(13-44)17-52(31)41(56)29-9-21-7-25(3-5-27(21)50-29)48-43(58)49-26-4-6-28-22(8-26)10-30(51-28)42(57)53-18-24(14-45)38-32(53)12-34(55)40-36(38)20(2)16-47-40/h3-12,15-16,23-24,46-47,50-51,54-55H,13-14,17-18H2,1-2H3,(H2,48,49,58)/t23-,24-/m1/s1

InChIKey

FONKWHRXTPJODV-DNQXCXABSA-N

Smiles

c12c(N(C(c3cc4cc(NC(Nc5cc6c([nH]c(c6)C(N6c7c(c8c([nH]cc8C)c(c7)O)[C@@H](C6)CCl)=O)cc5)=O)ccc4[nH]3)=O)C[C@H]2CCl)cc(O)c2c1c(c[nH]2)C