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Substance Name: Aripiprazole [USAN:INN:BAN]
RN: 129722-12-9
UNII: 82VFR53I78
InChIKey: CEUORZQYGODEFX-UHFFFAOYSA-N

Notes

  • A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.
  • Has both presynaptic dopamine autoreceptor agonistic activity and postsynaptic D2 receptor antagonistic activity; use associated with HYPERGLYCEMIA.

Molecular Formula

  • C23-H27-Cl2-N3-O2

Molecular Weight

  • 448.391
 

Classification Codes

  • Antidepressive Agents
  • Antipsychotic
  • Antipsychotic Agents
  • Antischizophrenic
  • Central Nervous System Agents
  • Central Nervous System Depressants
  • Dopamine Agents
  • Dopamine Agonists
  • Dopamine Antagonists
  • Dopamine D2 Receptor Antagonists
  • Neurotransmitter Agents
  • Psychotropic Drugs
  • Serotonin 5-HT1 Receptor Agonists
  • Serotonin 5-HT2 Receptor Antagonists
  • Serotonin Agents
  • Serotonin Antagonists
  • Serotonin Receptor Agonists
  • Tranquilizing Agents

Names and Synonyms

Name of Substance

  • Aripiprazole
  • Aripiprazole [USAN:INN:BAN]

MeSH Heading

  • Aripiprazole

Synonyms

  • 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-2(1H)-quinolinone
  • 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydrocarbostyril
  • 7-(4-(4-(2,3-Dichlorophenyl)-1-piperazinyl)butyloxy)-3,4-dihydro-2(1H)-quinolinone
  • Abilify
  • Abilify Digital
  • Abilify Discmelt
  • Abilify Maintena
  • Abilify Maintena Kit
  • Abilify MyCite
  • Abilitat
  • Aripiprazole
  • Discmelt
  • HSDB 7320
  • NSC 759266
  • Opc 14597
  • OPC 31
  • OPC-14597
  • OPC-31
  • UNII-82VFR53I78

Systematic Name

  • 2(1H)-Quinolinone, 7-(4-(4-(2,3-dichlorophenyl)-1-piperazinyl)butoxy)-3,4-dihydro-

Registry Numbers

CAS Registry Number

  • 129722-12-9

FDA UNII

  • 82VFR53I78

System Generated Number

  • 0129722129

Structure Descriptors

InChI

InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)

InChIKey

CEUORZQYGODEFX-UHFFFAOYSA-N

Smiles

Clc1cccc(N2CCN(CCCCOc3ccc4CCC(=O)Nc4c3)CC2)c1Cl