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Substance Name: Endothelin 3, big
RN: 129774-03-4


  • A 21-amino acid peptide that circulates in the plasma, but its source is not known. Endothelin-3 has been found in high concentrations in the brain and may regulate important functions in neurons and astrocytes, such as proliferation and development. It also is found throughout the gastrointestinal tract and in the lung and kidney. (N Eng J Med 1995;333(6):356-63)

Molecular Formula

  • Unspecified
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Names and Synonyms

MeSH Heading

  • Endothelin-3


  • Big endothelin 3
  • Big endothelin-3
  • Big ET-3

Systematic Name

  • Endothelin 3, big

Registry Numbers

CAS Registry Number

  • 129774-03-4

System Generated Number

  • 0129774034