Skip Navigation
ChemIDplus A TOXNET DATABASE LiteBrowseAdvanced

Substance Name: Thioridazine hydrochloride [USP:JAN]
RN: 130-61-0
UNII: 4WCI67NK8M
InChIKey: NZFNXWQNBYZDAQ-UHFFFAOYSA-N

Note

  • A phenothiazine antipsychotic used in the management of psychoses, including schizophrenia, and in the control of severely disturbed or agitated behavior. It has little antiemetic activity. Thioridazine has a higher incidence of antimuscarinic effects, but a lower incidence of extrapyramidal symptoms, than CHLORPROMAZINE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p618)

Molecular Formula

  • C21-H26-N2-S2.Cl-H

Molecular Weight

  • 407.0433
 

Classification Codes

  • Antipsychotic
  • Drug / Therapeutic Agent
  • Human Data
  • Mutation Data
  • Sedative-Hypnotic

Names and Synonyms

Name of Substance

  • Thioridazine hydrochloride [USP:JAN]

Synonyms

  • 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-(methylthio)phenothiazine monohydrochloride
  • 10-(2-(1-Methyl-2-piperidyl)ethyl)-2-methylthiophenothiazine hydrochloride
  • 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-, monohydrochloride
  • 2-Methylmercapto-10-(2-(N-methyl-2-piperidyl)ethyl)phenothiazine hydrochloride
  • EINECS 204-992-8
  • Mellaril
  • Mellaril hydrochloride
  • Melleril (tablet)
  • Melzine
  • NSC 186060
  • Sonapax hydrochloride
  • Thioridazine chloride
  • Thioridazine HCl
  • Thioridazine hydrochloride
  • Thioridazine hydrochloride intensol
  • UNII-4WCI67NK8M
  • USAF SZ-3
  • USAF SZ-B

Systematic Names

  • 10H-Phenothiazine, 10-(2-(1-methyl-2-piperidinyl)ethyl)-2-(methylthio)-, monohydrochloride
  • Phenothiazine, 10-(2-(1-methyl-2-piperidyl)ethyl)-2-(methylthio)-, monohydrochloride
  • Thioridazine hydrochloride

Registry Numbers

CAS Registry Number

  • 130-61-0

FDA UNII

  • 4WCI67NK8M

Other Registry Number

  • 107388-89-6

System Generated Number

  • 0000130610

Molecular Formulas

Molecular Formula

  • C21-H26-N2-S2.Cl-H

Molecular Formula Fragments

  • C21-H26-N2-S2
  • Cl-H
  • COMPONENT

Structure Descriptors

InChI

1S/C21H26N2S2.ClH/c1-22-13-6-5-7-16(22)12-14-23-18-8-3-4-9-20(18)25-21-11-10-17(24-2)15-19(21)23;/h3-4,8-11,15-16H,5-7,12-14H2,1-2H3;1H

InChIKey

NZFNXWQNBYZDAQ-UHFFFAOYSA-N

Smiles

CN1CCCCC1CCN2c3ccccc3Sc4c2cc(cc4)SC.Cl

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
dog LD50 oral 160mg/kg (160mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
mouse LD50 intraperitoneal 100mg/kg (100mg/kg)   National Technical Information Service. Vol. AD277-689,
mouse LD50 intravenous 33mg/kg (33mg/kg)   Therapie. Vol. 14, Pg. 793, 1959.
mouse LD50 oral 360mg/kg (360mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rabbit LD50 intravenous 26mg/kg (26mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rabbit LD50 oral 1100mg/kg (1100mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rat LD50 intravenous 71mg/kg (71mg/kg)   "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972Vol. -, Pg. 53, 1972.
rat LD50 oral 1060mg/kg (1060mg/kg)   Drugs in Japan Vol. 6, Pg. 458, 1982.
women TDLo oral 864mg/kg/18D- (864mg/kg) CARDIAC: PULSE RATE INCREASE WITHOUT FALL IN BP

ENDOCRINE: EVIDENCE OF THYROID HYPERFUNCTION
Postgraduate Medical Journal. Vol. 60, Pg. 445, 1984.