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Substance Name: Mafenide acetate [USP:JAN]
RN: 13009-99-9
UNII: RQ6LP6Z0WY
InChIKey: UILOTUUZKGTYFQ-UHFFFAOYSA-N

Classification Codes

  • Anti-Infective Agents
  • Anti-Infective Agents, Local
  • Anti-Infective, Topical
  • Drug / Therapeutic Agent
  • Reproductive Effect

Molecular Formula

  • C7-H10-N2-O2-S.C2-H4-O2

Molecular Weight

  • 246.2856
 
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Names and Synonyms

Name of Substance

  • Mafenide acetate [USP:JAN]

MeSH Heading

  • Mafenide

Synonyms

  • 4-(Aminomethyl)benzenesulfonamide monoacetate
  • alpha-Amino-p-toluenesulfonamide monoacetate
  • EINECS 235-855-0
  • Mafatate
  • Mafenide acetate
  • Maphenide acetate
  • p-Aminomethylbenzenesulfonamide acetate
  • Sulfamilon
  • Sulfamylon
  • UNII-RQ6LP6Z0WY
  • Winthrocine

Systematic Names

  • alpha-Aminotoluene-4-sulphonamide monoacetate
  • Benzenesulfonamide, 4-(aminomethyl)-, monoacetate
  • p-Toluenesulfonamide, alpha-amino-, monoacetate

Registry Numbers

CAS Registry Number

  • 13009-99-9

FDA UNII

  • RQ6LP6Z0WY

System Generated Number

  • 0013009999

Molecular Formulas

Molecular Formula

  • C7-H10-N2-O2-S.C2-H4-O2

Molecular Formula Fragments

  • C2-H4-O2
  • C7-H10-N2-O2-S
  • COMPONENT

Structure Descriptors

InChI

1S/C7H10N2O2S.C2H4O2/c8-5-6-1-3-7(4-2-6)12(9,10)11;1-2(3)4/h1-4H,5,8H2,(H2,9,10,11);1H3,(H,3,4)

InChIKey

UILOTUUZKGTYFQ-UHFFFAOYSA-N

Smiles

CC(=O)O.c1cc(ccc1CN)S(=O)(=O)N

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 oral 5425mg/kg (5425mg/kg) LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mammal (species unspecified) LC inhalation > 320mg/m3 (320mg/m3)   Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse LD50 intraperitoneal 2322mg/kg (2322mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse LD50 intravenous 1580mg/kg (1580mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Life Sciences. Vol. 5, Pg. 2279, 1966.
mouse LD50 oral 10183mg/kg (10183mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
mouse LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: MUSCLE WEAKNESS
Yakkyoku. Pharmacy. Vol. 30, Pg. 1517, 1979.
rat LD50 intraperitoneal 1560mg/kg (1560mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 884, 1979.
rat LD50 intravenous 1730mg/kg (1730mg/kg)   Iyakuhin Kenkyu. Study of Medical Supplies. Vol. 10, Pg. 884, 1979.
rat LD50 oral 9212mg/kg (9212mg/kg) BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)

BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY)

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. Vol. 31(8), Pg. 50, 1987.
rat LD50 subcutaneous > 5gm/kg (5000mg/kg) BEHAVIORAL: MUSCLE WEAKNESS

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)
Yakkyoku. Pharmacy. Vol. 30, Pg. 1517, 1979.