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Substance Name: Lomustine [USAN:INN:BAN]
RN: 13010-47-4
UNII: 7BRF0Z81KG
InChIKey: GQYIWUVLTXOXAJ-UHFFFAOYSA-N
Note
- An alkylating agent of value against both hematologic malignancies and solid tumors.
Molecular Formula
- C9-H16-Cl-N3-O2
Molecular Weight
- 233.6974
- All
- Classifications
- Links to Resources
- Names & Synonyms
- Registry Numbers
- Structure Descriptors
- Toxicity
- Physical Properties
Classification Codes
Classification Codes
- Alkylating Agents
- Antineoplastic
- Antineoplastic Agents
- Antineoplastic Agents, Alkylating
- Drug / Therapeutic Agent
- Human Data
- Mutation Data
- Noxae
- Reproductive Effect
- Tumor Data
Superlist Classification Codes
- Overall Carcinogenic Evaluation: Group 2A
- Reasonably Anticipated to be a Carcinogen
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Names and Synonyms
Name of Substance
- Lomustine
- Lomustine [USAN:INN:BAN]
MeSH Heading
- Lomustine
Synonyms
- (Chloro-2-ethyl)-1-cyclohexyl-3-nitrosourea
- (Cloro-2-etil)-1-cicloesil-3-nitrosourea
- (Cloro-2-etil)-1-cicloesil-3-nitrosourea [Italian]
- 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
- 1-(2-Chloroethyl)-3-cyclohexylnitrosourea
- 1-Nitrosourea, 1-(2-chloroethyl)-3-cyclohexyl-
- AI3-52779
- Belustine
- BRN 2125058
- CCNU
- CCRIS 860
- Cecenu
- CeeNU
- Chloroethylcyclohexylnitrosourea
- CINU
- Cyclohexyl chloroethyl nitrosourea
- EINECS 235-859-2
- Gleostine
- HSDB 6519
- ICIG 1109
- Lomustina
- Lomustina [INN-Spanish]
- Lomustine
- Lomustinum
- Lomustinum [INN-Latin]
- N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
- NCI-C04740
- NSC 79037
- NSC-79037
- RB 1509
- SRI 2200
- UNII-7BRF0Z81KG
- Urea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-
Systematic Names
- Lomustine
- N-(2-Chloroethyl)-N'-cyclohexyl-N-nitrosourea
- Urea, 1-(2-chloroethyl)-3-cyclohexyl-1-nitroso-
- Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-
Superlist Names
- 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea
- 1-(2-Chloroethyl)-3-cyclohexyl-1-nitrosourea [Chloroethyl nitrosoureas]
- CCNU
- CCNU [Chloroethyl nitrosoureas]
- Lomustine
- Urea, N-(2-chloroethyl)-N'-cyclohexyl-N-nitroso-
Registry Numbers
CAS Registry Number
- 13010-47-4
FDA UNII
- 7BRF0Z81KG
System Generated Number
- 0013010474
Structure Descriptors
InChI
InChI=1S/C9H16ClN3O2/c10-6-7-13(12-15)9(14)11-8-4-2-1-3-5-8/h8H,1-7H2,(H,11,14)InChIKey
GQYIWUVLTXOXAJ-UHFFFAOYSA-NSmiles
ClCCN(N=O)Toxicity
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
dog | LDLo | intravenous | 5mg/kg (5mg/kg) | Cancer Chemotherapy Reports, Part 3. Vol. 4(3), Pg. 13, 1973. | |
dog | LDLo | oral | 10mg/kg (10mg/kg) | Advances in Cancer Research. Vol. 16, Pg. 273, 1972. | |
human | TDLo | oral | 3mg/kg (3mg/kg) | BLOOD: LEUKOPENIA BLOOD: THROMBOCYTOPENIA GASTROINTESTINAL: NAUSEA OR VOMITING | Cancer Treatment Reports. Vol. 60, Pg. 709, 1976. |
human | TDLo | oral | 30mg/kg (30mg/kg) | BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING | Cancer Chemotherapy Reports, Part 3. Vol. 3, Pg. 33, 1972. |
monkey | LDLo | intravenous | 20mg/kg (20mg/kg) | National Technical Information Service. Vol. PB214-246, | |
monkey | LDLo | intravenous | 20mg/kg (20mg/kg) | BLOOD: OTHER HEMOLYSIS WITH OR WITHOUT ANEMIA KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | National Technical Information Service. Vol. PB214-246, |
mouse | LD10 | intravenous | 40mg/kg (40mg/kg) | Antibiotics and Chemotherapy Vol. 23, Pg. 64, 1978. | |
mouse | LD50 | intraperitoneal | 53mg/kg (53mg/kg) | GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Toxicology and Applied Pharmacology. Vol. 21, Pg. 405, 1972. |
mouse | LD50 | oral | 38mg/kg (38mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" | Toxicology and Applied Pharmacology. Vol. 21, Pg. 405, 1972. |
mouse | LD50 | subcutaneous | 54mg/kg (54mg/kg) | KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" | Toxicology and Applied Pharmacology. Vol. 21, Pg. 405, 1972. |
mouse | LD50 | unreported | 30mg/kg (30mg/kg) | European Journal of Medicinal Chemistry--Chimie Therapeutique. Vol. 12, Pg. 397, 1977. | |
rat | LD50 | intraperitoneal | 50350ug/kg (50.35mg/kg) | National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. Vol. JAN1986, | |
rat | LD50 | oral | 70mg/kg (70mg/kg) | LIVER: "JAUNDICE, OTHER OR UNCLASSIFIED" GASTROINTESTINAL: "HYPERMOTILITY, DIARRHEA" KIDNEY, URETER, AND BLADDER: URINE VOLUME INCREASED | Toxicology and Applied Pharmacology. Vol. 21, Pg. 405, 1972. |
women | LDLo | oral | 28mg/kg/1W-I (28mg/kg) | Annals of Pharmacotherpy. Vol. 29, Pg. 384, 1995. | |
women | LDLo | oral | 28mg/kg/1W-I (28mg/kg) | BLOOD: APLASTIC ANEMIA BEHAVIORAL: "HALLUCINATIONS, DISTORTED PERCEPTIONS" | Annals of Pharmacotherpy. Vol. 29, Pg. 384, 1995. |
Physical Properties
Physical Property | Value | Units | Temp (deg C) | Source |
---|---|---|---|---|
Melting Point | 88-90 | deg C | EXP | |
log P (octanol-water) | 2.83 | (none) | EXP | |
Water Solubility | 111 | mg/L | 25 | EST |
Vapor Pressure | 1.01E-05 | mm Hg | 25 | EST |
Henry's Law Constant | 1.85E-10 | atm-m3/mole | 25 | EST |
Atmospheric OH Rate Constant | 2.19E-11 | cm3/molecule-sec | 25 | EST |
Physical property data is provided to ChemIDplus by SRC, Inc.