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Substance Name: SAR-405838
RN: 1303607-60-4
UNII: 8570LZ3RCA
InChIKey: IDKAKZRYYDCJDU-HBMMIIHUSA-N

Note

  • An inhibitor of the interaction of MDM2 and p53; has antineoplastic activity.

Molecular Formula

  • C29-H34-Cl2-F-N3-O3

Molecular Weight

  • 562.5096
 
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Names and Synonyms

Name of Substance

  • SAR-405838

Synonyms

  • (2'S,3'R,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluoro-phenyl)-2'-(2,2-dimethyl-propyl)-2-oxo-1,2-dihydro-spiro (indole-3,3'-pyrrolidine)-5'-carboxylic acid (trans-4-hydroxy-cyclohexyl)-amide
  • (2'S,3R,4'S,5'R)-6-Chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-N-(trans-4-hydroxycyclohexyl)-2-oxo-1,2-dihydrospiro(indole-3,3'-pyrrolidine)-5'-carboxamide
  • MI-77301
  • SAR-405838
  • SAR405838
  • Spiro(3H-indole-3,3'-pyrrolidine)-5'-carboxamide, 6-chloro-4'-(3-chloro-2-fluorophenyl)-2'-(2,2-dimethylpropyl)-1,2-dihydro-N-(trans-4-hydroxycyclohexyl)-2-oxo-, (2'S,3R,4'S,5'R)-
  • UNII-8570LZ3RCA

Registry Numbers

CAS Registry Number

  • 1303607-60-4

FDA UNII

  • 8570LZ3RCA

System Generated Number

  • 1303607604

Structure Descriptors

InChI

1S/C29H34Cl2FN3O3/c1-28(2,3)14-22-29(19-12-7-15(30)13-21(19)34-27(29)38)23(18-5-4-6-20(31)24(18)32)25(35-22)26(37)33-16-8-10-17(36)11-9-16/h4-7,12-13,16-17,22-23,25,35-36H,8-11,14H2,1-3H3,(H,33,37)(H,34,38)/t16-,17-,22-,23-,25+,29+/m0/s1

InChIKey

IDKAKZRYYDCJDU-HBMMIIHUSA-N

Smiles

CC(C[C@@H]1N[C@H]([C@@H]([C@]12C(=O)Nc3c2ccc(c3)Cl)c4c(c(ccc4)Cl)F)C(=O)N[C@H]5CC[C@@H](CC5)O)(C)C