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Substance Name: Lucimycin [INN]
RN: 13058-67-8
UNII: 3K1B4B63D0
InChIKey: MUAOHYJGHYFDSA-YZMLMZOASA-N

Note

  • A macrolide antibiotic isolated from cultures of Streptomyces lucensis.

Molecular Formula

  • C36-H53-N-O13

Molecular Weight

  • 707.8087
 

Classification Codes

  • Anti-Bacterial Agents
  • Anti-Infective Agents
  • Antifungal Agents
  • Mutation Data
  • Natural Product
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Names and Synonyms

Name of Substance

  • Lucensomycin
  • Lucimycin [INN]

MeSH Heading

  • Lucensomycin

Synonyms

  • Antibiotic 1163 F.I.
  • EINECS 235-950-7
  • Etruscomicina
  • Etruscomycin
  • FI 1163
  • Leusensomycin
  • Lucimicina
  • Lucimicina [INN-Spanish]
  • Lucimycin
  • Lucimycine
  • Lucimycine [INN-French]
  • Lucimycinum
  • Lucimycinum [INN-Latin]
  • NSC 143257
  • Stereoisomer of 22-((3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy)-12-butyl-1,3,26-trihydroxy-10-oxo-6,11,28-trioxatricyclo(33.3.1.05,7)octacosa-8,14,16,18,20-pentaene-25-carboxylic acid
  • UNII-3K1B4B63D0

Systematic Names

  • 6,11,28-Trioxatricyclo(22.3.1.05,7)octacowq-8,14,16,18,20-pentaene-25-carboxylic acid, 22-((3-amino-3,6-dideoxy-beta-D-mannopyranosyl)oxy)-12-butyl-1,3,26-trihydroxy-10-oxo-
  • Antibiotic obtained from cultures of Streptomyces lucensis, or the same substance produced by any other means
  • Lucensomycin

Registry Numbers

CAS Registry Number

  • 13058-67-8

FDA UNII

  • 3K1B4B63D0

Other Registry Numbers

  • 11013-29-9
  • 11035-14-6
  • 24032-56-2
  • 4009-47-6
  • 51273-85-9

System Generated Number

  • 0013058678

Structure Descriptors

InChI

1S/C36H53NO13/c1-3-4-12-23-13-10-8-6-5-7-9-11-14-24(48-35-33(42)31(37)32(41)21(2)46-35)18-28-30(34(43)44)25(39)20-36(45,50-28)19-22(38)17-27-26(49-27)15-16-29(40)47-23/h5-11,14-16,21-28,30-33,35,38-39,41-42,45H,3-4,12-13,17-20,37H2,1-2H3,(H,43,44)/b6-5+,9-7+,10-8+,14-11+,16-15+/t21-,22+,23?,24+,25+,26-,27-,28+,30-,31+,32-,33+,35+,36-/m1/s1

InChIKey

MUAOHYJGHYFDSA-YZMLMZOASA-N

Smiles

CCCCC1C\C=C\C=C\C=C\C=C\[C@@H](C[C@@H]2O[C@](O)(C[C@@H](O)C[C@H]3O[C@@H]3\C=C\C(=O)O1)C[C@H](O)[C@H]2C(=O)O)O[C@@H]4O[C@H](C)[C@@H](O)[C@H](N)[C@@H]4O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
mouse LD50 intraperitoneal 37mg/kg (37mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 967, 1978.
mouse LD50 intravenous 45mg/kg (45mg/kg)   "Antibiotics: Origin, Nature, and Properties," Korzyoski, T., et al., eds., Washington, DC, American Soc. for Microbiology, 1978Vol. 2, Pg. 967, 1978.
mouse LD50 oral 1263mg/kg (1263mg/kg)   "Merck Index; an Encyclopedia of Chemicals, Drugs, and Biologicals", 11th ed., Rahway, NJ 07065, Merck & Co., Inc. 1989Vol. 11, Pg. 879, 1989.