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Substance Name: Iothalamate meglumine [USP]
RN: 13087-53-1
UNII: XUW72GOP7W
InChIKey: VLHUSFYMPUDOEL-WZTVWXICSA-N

Note

  • A radiopaque medium used for urography, angiography, venography, and myelography. It is highly viscous and binds to plasma proteins.

Molecular Formula

  • C11-H9-I3-N2-O4.C7-H17-N-O5

Molecular Weight

  • 809.1154
 

Classification Codes

  • Contrast Media
  • Diagnostic Aid (Radiopaque Medium)
  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Name of Substance

  • Iothalamate meglumine
  • Iothalamate meglumine [USP]

MeSH Heading

  • Iothalamate meglumine

Synonyms

  • 1-Deoxy-1-(methylamino)-D-glucitol 5-acetamido-2,4,6-triiodo-N-methylisophthalamate (salt)
  • Benzoic acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:1)
  • Conray
  • Conray 280
  • Conray 30
  • Conray 43
  • Conray 60
  • Conray meglumin
  • Conray meglumine 282
  • Contrix 28
  • Cysto-Conray
  • Cysto-conray II
  • EINECS 235-998-9
  • Iotalamate de methylglucamine
  • Iotalamate de methylglucamine [French]
  • Iothalamate meglumine
  • Iothalamate methylglucamine
  • Iothalamate methylglucamine salt
  • Iothalamic acid N-methylgucamine salt
  • Jotalamsaeure methylglucaminesalz
  • Jotalamsaeure methylglucaminesalz [German]
  • Meglumine conray
  • Meglumine iotalamate
  • Meglumine iotalamate injection
  • Meglumine iothalamate
  • Meglumine Iothalamate [BAN]
  • Meglumine isothalamate
  • Methylglucamine iotalamate
  • Methylglucamine iothalamate
  • UNII-XUW72GOP7W

Systematic Names

  • 1-Deoxy-1-(methylamino)-D-glucitol 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate
  • Benzoic acid, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:1)
  • D-Glucitol, 1-deoxy-1-(methylamino)-, 3-(acetylamino)-2,4,6-triiodo-5-((methylamino)carbonyl)benzoate (salt)
  • Isophthalamic acid, 5-acetamido-2,4,6-triiodo-N-methyl-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:1)

Mixture Name

  • Vascoray

Registry Numbers

CAS Registry Number

  • 13087-53-1

FDA UNII

  • XUW72GOP7W

Other Registry Numbers

  • 16240-57-6
  • 519-25-5

System Generated Number

  • 0013087531

Molecular Formulas

Molecular Formula

  • C11-H9-I3-N2-O4.C7-H17-N-O5

Molecular Formula Fragments

  • C11-H9-I3-N2-O4
  • C7-H17-N-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C11H9I3N2O4.C7H17NO5/c1-3(17)16-9-7(13)4(10(18)15-2)6(12)5(8(9)14)11(19)20;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2H3,(H,15,18)(H,16,17)(H,19,20);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

InChIKey

VLHUSFYMPUDOEL-WZTVWXICSA-N

Smiles

CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.CNC(=O)c1c(I)c(NC(=O)C)c(I)c(C(=O)O)c1I

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LD50 intraperitoneal 14gm/kg (14000mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
mouse LD50 intracrebral 220mg/kg (220mg/kg)   Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
mouse LD50 intraperitoneal 22741mg/kg (22741mg/kg)   Acta Radiologica, Supplementum. Vol. 335, Pg. 5, 1973.
mouse LD50 intravenous 8100mg/kg (8100mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
rabbit LD50 intravenous 18065mg/kg (18065mg/kg)   Acta Radiologica, Supplementum. Vol. 335, Pg. 5, 1973.
rat LD50 intracrebral 205mg/kg (205mg/kg)   Drugs in Japan Vol. 6, Pg. 64, 1982.
rat LD50 intraperitoneal 19800mg/kg (19800mg/kg) CARDIAC: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
rat LD50 intravenous 10500mg/kg (10500mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

CARDIAC: OTHER CHANGES
Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 222, 1965.
rat LD50 unreported 13600mg/kg (13600mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 921, 1984.
women TDLo intracrebral 20mg/kg (20mg/kg) BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD Anaesthesia. Vol. 27, Pg. 454, 1972.