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Substance Name: Silmitasertib sodium
RN: 1309357-15-0
UNII: N1E607PU86
InChIKey: ODDAAPQSODILSN-UHFFFAOYSA-M

Note

  • NCI: An orally bioavailable small-molecule inhibitor of CK2 with potential antineoplastic activity. Silmitasertib selectively binds to and inhibits the enzyme casein kinase II (CK2), which may lead to an inhibition of cellular proliferation. CK2, a protein kinase often overexpressed in a variety of cancer cell types, appears to be correlated with malignant transformation, tumor growth and survival. (NCI Thesaurus)

Molecular Formula

  • C19-H11-Cl-N3-O2.Na

Molecular Weight

  • 371.7579
 
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Names and Synonyms

Name of Substance

  • Silmitasertib sodium

Synonyms

  • 5-((3-Chlorophenyl)amino)-benzo(C)-2,6-naphthyridine-8-carboxylic acid sodium salt
  • Benzo(C)-2,6-naphthyridine-8-carboxylic acid, 5-((3-chlorophenyl)amino)-, sodium salt (1:1)
  • Silmitasertib sodium
  • UNII-N1E607PU86

Registry Numbers

CAS Registry Number

  • 1309357-15-0

FDA UNII

  • N1E607PU86

System Generated Number

  • 1309357150

Structure Descriptors

InChI

1S/C19H12ClN3O2.Na/c20-12-2-1-3-13(9-12)22-18-15-6-7-21-10-16(15)14-5-4-11(19(24)25)8-17(14)23-18;/h1-10H,(H,22,23)(H,24,25);/q;+1/p-1

InChIKey

ODDAAPQSODILSN-UHFFFAOYSA-M

Smiles

c1cc(cc(c1)Cl)Nc2c3ccncc3c4ccc(cc4n2)C(=O)[O-].[Na+]