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Substance Name: Diatrizoate meglumine [USP]
RN: 131-49-7
UNII: 3X9MR4N98U
InChIKey: MIKKOBKEXMRYFQ-WZTVWXICSA-N

Note

  • A versatile contrast medium used for DIAGNOSTIC X-RAY RADIOLOGY.

Molecular Formula

  • C11-H9-I3-N2-O4.C7-H17-N-O5

Molecular Weight

  • 809.1154
 

Classification Codes

  • Contrast Media
  • Diagnostic Aid (Radiopaque Medium)
  • Diagnostic Uses of Chemicals
  • Drug / Therapeutic Agent
  • Human Data
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Names and Synonyms

Name of Substance

  • Diatrizoate meglumine
  • Diatrizoate meglumine [USP]

MeSH Heading

  • Diatrizoate meglumine

Synonyms

  • 1-Deoxy-1-(methylamino)-D-glucitol 3,5-diacetamido-2,4,6-triiodobenzoate (salt)
  • 3,5-Bis(acetamido)-2,4,6-triiodbenzoesaeure, 1-desoxy-1-methylamino-D-glucit-salz
  • Amidotrizoate meglumine
  • Angiografin
  • Angiovist 282
  • Benzoic acid, 3,5-diacetamido-2,4,6-triiodo-, compd. with 1-deoxy-1-(methylamino)-D-glucitol
  • Cardiografin
  • Cystografin
  • Cystografin Dilute
  • Cystographin Dilute
  • D-Glucitol, 1-deoxy-1-(methylamino)-, 3,5-bis(acetylamino)-2,4,6-triiodobenzoate (salt)
  • Diatrizoate meglumine
  • Diatrizoate methylglucamine
  • EINECS 205-024-7
  • Gastrografin
  • Gastrografin Oral (Veterinary)
  • Hypaque
  • Hypaque 13.4
  • Hypaque 60
  • Hypaque Cysto
  • Hypaque M 30
  • Hypaque Meglumine
  • Hypaque-cysto
  • Hypaque-DIU
  • MD 60
  • Meglumine amidotrizoate
  • Meglumine amidotrizoate injection
  • Meglumine diatrizoate
  • Methylglucamine diatrizoate
  • Reno
  • RENO M 60
  • Reno-30
  • Reno-60
  • Reno-DIP
  • Reno-M
  • Reno-M-Dip
  • Renocal
  • Renograffin M-76
  • Renografin
  • Renovist
  • Renurix
  • Sinografin
  • UNII-3X9MR4N98U
  • Unipaque
  • Urovist
  • Urovist cysto
  • Urovist cysto pediatric
  • Urovist meglumine DIU/CT

Systematic Names

  • Benzoic acid, 3,5-bis(acetylamino)-2,4,6-triiodo-, compd. with 1-deoxy-1-(methylamino)-D-glucitol (1:1)
  • D-Glucitol, 1-deoxy-1-(methylamino)-, 3,5-bis(acetylamino)-2,4,6-triiodobenzoate (salt)
  • Glucitol, 1-deoxy-1-(methylamino)-, 3,5-diacetamido-2,4,6-triiodobenzoate (salt), D-
  • Meglumine diatrizoate

Mixture Names

  • Gastrografin
  • Hypaque

Registry Numbers

CAS Registry Number

  • 131-49-7

FDA UNII

  • 3X9MR4N98U

Other Registry Numbers

  • 146-69-0
  • 19766-67-7
  • 63626-48-2
  • 69426-25-1
  • 7170-91-4

System Generated Number

  • 0000131497

Molecular Formulas

Molecular Formula

  • C11-H9-I3-N2-O4.C7-H17-N-O5

Molecular Formula Fragments

  • C11-H9-I3-N2-O4
  • C7-H17-N-O5
  • COMPONENT

Structure Descriptors

InChI

1S/C11H9I3N2O4.C7H17NO5/c1-3(17)15-9-6(12)5(11(19)20)7(13)10(8(9)14)16-4(2)18;1-8-2-4(10)6(12)7(13)5(11)3-9/h1-2H3,(H,15,17)(H,16,18)(H,19,20);4-13H,2-3H2,1H3/t;4-,5+,6+,7+/m.0/s1

InChIKey

MIKKOBKEXMRYFQ-WZTVWXICSA-N

Smiles

CC(=O)Nc1c(c(c(c(c1I)NC(=O)C)I)C(=O)O)I.CNC[C@@H]([C@H]([C@@H]([C@@H](CO)O)O)O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
man TDLo subcutaneous 214mg/kg (214mg/kg) KIDNEY, URETER, AND BLADDER: CHANGES IN BOTH TUBULES AND GLOMERULI

KIDNEY, URETER, AND BLADDER: INTERSTITIAL NEPHRITIS

KIDNEY, URETER, AND BLADDER: URINE VOLUME DECREASED
"Toxicology of Drugs and Chemicals," Deichmann, W.B., New York, Academic Press, Inc., 1969Vol. -, Pg. 392, 1969.
mouse LD50 intracrebral 80mg/kg (80mg/kg) BEHAVIORAL: EXCITEMENT

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

BRAIN AND COVERINGS: RECORDINGS FROM SPECIFIC AREAS OF CNS
Therapie. Vol. 26, Pg. 595, 1971.
mouse LD50 intravenous 21200mg/kg (21200mg/kg)   Drugs in Japan Vol. 6, Pg. 32, 1982.
rat LD50 intravenous 14565mg/kg (14565mg/kg)   AJR, American Journal of Roentgenology. Vol. 142, Pg. 619, 1984.
rat LD50 parenteral 44504mg/kg (44504mg/kg)   AJR, American Journal of Roentgenology. Vol. 142, Pg. 619, 1984.
rat LD50 unreported 19500mg/kg (19500mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 26, Pg. 921, 1984.