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Substance Name: Germanium dioxide
RN: 1310-53-8
UNII: 5O6CM4W76A
InChIKey: YBMRDBCBODYGJE-UHFFFAOYSA-N

Note

  • Has antimutagenic effects.

Molecular Formula

  • Ge-O2

Molecular Weight

  • 104.608
 

Classification Codes

  • Antimutagenic Agents
  • Protective Agents
  • Reproductive Effect
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Names and Synonyms

Name of Substance

  • Germanium dioxide
  • Germanium oxide

Synonyms

  • EINECS 215-180-8
  • Germania
  • Germanic acid
  • Germanic oxide (crystalline)
  • Germanium oxide
  • Germanium oxide (GeO2)
  • HSDB 2119
  • NSC 294212
  • UNII-5O6CM4W76A

Systematic Names

  • Germanium dioxide
  • Germanium oxide (GeO2)

Registry Numbers

CAS Registry Number

  • 1310-53-8

FDA UNII

  • 5O6CM4W76A

Other Registry Numbers

  • 12687-69-3
  • 1971950-71-6

System Generated Number

  • 0001310538

Structure Descriptors

InChI

InChI=1S/GeO2/c2-1-3

InChIKey

YBMRDBCBODYGJE-UHFFFAOYSA-N

Smiles

O=[Ge]=O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
guinea pig LDLo intraperitoneal 400mg/kg (400mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
man TDLo oral 1614mg/kg/22W (1614mg/kg) BEHAVIORAL: ANOREXIA (HUMAN

GASTROINTESTINAL: NAUSEA OR VOMITING

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Nephron. Vol. 54, Pg. 53, 1990.
mouse LD50 intraperitoneal 1550mg/kg (1550mg/kg) BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 671, 1978.
mouse LD50 oral 1250mg/kg (1250mg/kg)   "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 71, 1982.
mouse LD50 subcutaneous 2550mg/kg (2550mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 773, 1981.
rabbit LD50 subcutaneous 845mg/kg (845mg/kg)   Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975.
rat LC50 inhalation > 1420mg/m3/4H (1420mg/m3) SKIN AND APPENDAGES (SKIN): HAIR: OTHER

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Food and Chemical Toxicology. Vol. 32, Pg. 1037, 1994.
rat LD50 intraperitoneal 750mg/kg (750mg/kg) LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA

LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION
AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 466, 1953.
rat LD50 oral 1250mg/kg (1250mg/kg)   "Investigations in the Field of Organogermanium Chemistry," Rijkens, F., and G.J.M. Van Der Kerk, Utrecht, Netherlands, Schotanus & Jens Utrecht N.V., 1964Vol. -, Pg. 95, 1964.
rat LD50 subcutaneous 1910mg/kg (1910mg/kg)   Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 773, 1981.
women TDLo oral 1660mg/kg/17W (1660mg/kg) GASTROINTESTINAL: NAUSEA OR VOMITING

BEHAVIORAL: ANOREXIA (HUMAN

KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)"
Nephron. Vol. 54, Pg. 53, 1990.