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Substance Name: Germanium dioxide
RN: 1310-53-8
UNII: 5O6CM4W76A
InChIKey: YBMRDBCBODYGJE-UHFFFAOYSA-N
Note
- Has antimutagenic effects.
Molecular Formula
- Ge-O2
Molecular Weight
- 104.608
Classification Codes
- Antimutagenic Agents
- Protective Agents
- Reproductive Effect
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Names and Synonyms
Name of Substance
- Germanium dioxide
- Germanium oxide
Synonyms
- EINECS 215-180-8
- Germania
- Germanic acid
- Germanic oxide (crystalline)
- Germanium oxide
- Germanium oxide (GeO2)
- HSDB 2119
- NSC 294212
- UNII-5O6CM4W76A
Systematic Names
- Germanium dioxide
- Germanium oxide (GeO2)
Registry Numbers
CAS Registry Number
- 1310-53-8
FDA UNII
- 5O6CM4W76A
Other Registry Numbers
- 12687-69-3
- 1971950-71-6
System Generated Number
- 0001310538
Structure Descriptors
InChI
InChI=1S/GeO2/c2-1-3InChIKey
YBMRDBCBODYGJE-UHFFFAOYSA-NSmiles
O=[Ge]=OToxicity
| Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
|---|---|---|---|---|---|
| guinea pig | LDLo | intraperitoneal | 400mg/kg (400mg/kg) | Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975. | |
| man | TDLo | oral | 1614mg/kg/22W (1614mg/kg) | BEHAVIORAL: ANOREXIA (HUMAN GASTROINTESTINAL: NAUSEA OR VOMITING KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Nephron. Vol. 54, Pg. 53, 1990. |
| mouse | LD50 | intraperitoneal | 1550mg/kg (1550mg/kg) | BEHAVIORAL: CHANGES IN MOTOR ACTIVITY (SPECIFIC ASSAY) | Oyo Yakuri. Pharmacometrics. Vol. 16, Pg. 671, 1978. |
| mouse | LD50 | oral | 1250mg/kg (1250mg/kg) | "Toxicometric Parameters of Industrial Toxic Chemicals Under Single Exposure," Izmerov, N.F., et al., Moscow, Centre of International Projects, GKNT, 1982Vol. -, Pg. 71, 1982. | |
| mouse | LD50 | subcutaneous | 2550mg/kg (2550mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 773, 1981. | |
| rabbit | LD50 | subcutaneous | 845mg/kg (845mg/kg) | Environmental Quality and Safety, Supplement. Vol. 1, Pg. 1, 1975. | |
| rat | LC50 | inhalation | > 1420mg/m3/4H (1420mg/m3) | SKIN AND APPENDAGES (SKIN): HAIR: OTHER LUNGS, THORAX, OR RESPIRATION: DYSPNEA | Food and Chemical Toxicology. Vol. 32, Pg. 1037, 1994. |
| rat | LD50 | intraperitoneal | 750mg/kg (750mg/kg) | LUNGS, THORAX, OR RESPIRATION: CHRONIC PULMONARY EDEMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION | AMA Archives of Industrial Hygiene and Occupational Medicine. Vol. 8, Pg. 466, 1953. |
| rat | LD50 | oral | 1250mg/kg (1250mg/kg) | "Investigations in the Field of Organogermanium Chemistry," Rijkens, F., and G.J.M. Van Der Kerk, Utrecht, Netherlands, Schotanus & Jens Utrecht N.V., 1964Vol. -, Pg. 95, 1964. | |
| rat | LD50 | subcutaneous | 1910mg/kg (1910mg/kg) | Oyo Yakuri. Pharmacometrics. Vol. 21, Pg. 773, 1981. | |
| women | TDLo | oral | 1660mg/kg/17W (1660mg/kg) | GASTROINTESTINAL: NAUSEA OR VOMITING BEHAVIORAL: ANOREXIA (HUMAN KIDNEY, URETER, AND BLADDER: "CHANGES IN TUBULES (INCLUDING ACUTE RENAL FAILURE, ACUTE TUBULAR NECROSIS)" | Nephron. Vol. 54, Pg. 53, 1990. |