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Substance Name: Fonazine mesylate [USAN]
RN: 13115-40-7
UNII: B28V86NGNK
InChIKey: JGKVKXPDDVRUKC-UHFFFAOYSA-N

Note

  • Has considerable antiemetic & serotonin antagonistic action used mainly in allergic skin conditions.

Molecular Formula

  • C19-H25-N3-O2-S2.C-H4-O3-S

Molecular Weight

  • 487.6631
 

Classification Codes

  • Reproductive Effect
  • Serotonin Inhibitor
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Names and Synonyms

Name of Substance

  • Dimetotiazine mesilate [JAN]
  • Fonazine mesylate [USAN]

Synonyms

  • 10-(2-(Dimethylamino)propyl)-N,N-dimethylphenothiazine-2-sulfonamide methanesulfonate
  • 8599 R.P. mesylate
  • 8599RP mesylate
  • Banistyl
  • Bonpac
  • Calsekin
  • Dimethothiazine mesylate
  • Dimethothiazine methanesulfonate
  • Dimetotiazine mesilate
  • EINECS 236-041-8
  • Fonazine mesylate
  • Fonazine methanesulfonate
  • IL-6302 mesylate
  • Migristene
  • Neomestine
  • Promaquid
  • RP 8599 mesylate
  • UNII-B28V86NGNK
  • Yoristen

Systematic Names

  • 10-(2-(Dimethylamino)propyl)-N,N-dimethyl-10H-phenothiazine-2-sulphonamide monomethanesulphonate
  • 10H-Phenothiazine-2-sulfonamide, 10-(2-(dimethylamino)propyl)-N,N-dimethyl-, monomethanesulfonate
  • Phenothiazine-2-sulfonamide, 10-(2-(dimethylamino)propyl)-N,N-dimethyl-, monomethanesulfonate

Registry Numbers

CAS Registry Number

  • 13115-40-7

FDA UNII

  • B28V86NGNK

Other Registry Number

  • 7455-39-2

Related Registry Number

  • 7456-24-8 (Parent)

System Generated Number

  • 0013115407

Molecular Formulas

Molecular Formula

  • C19-H25-N3-O2-S2.C-H4-O3-S

Molecular Formula Fragments

  • C-H4-O3-S
  • C19-H25-N3-O2-S2
  • COMPONENT

Structure Descriptors

InChI

1S/C19H25N3O2S2.CH4O3S/c1-14(20(2)3)13-22-16-8-6-7-9-18(16)25-19-11-10-15(12-17(19)22)26(23,24)21(4)5;1-5(2,3)4/h6-12,14H,13H2,1-5H3;1H3,(H,2,3,4)

InChIKey

JGKVKXPDDVRUKC-UHFFFAOYSA-N

Smiles

CC(CN1c2ccccc2Sc3c1cc(cc3)S(=O)(=O)N(C)C)N(C)C.CS(=O)(=O)O

Toxicity

Organism Test Type Route Reported Dose (Normalized Dose) Effect Source
cat LDLo oral 250mg/kg (250mg/kg) SENSE ORGANS AND SPECIAL SENSES: MYDRIASIS (PUPILLARY DILATION): EYE

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.
dog LDLo oral 250mg/kg (250mg/kg)   Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.
dog LDLo oral 250mg/kg (250mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.
guinea pig LDLo oral 500mg/kg (500mg/kg) LUNGS, THORAX, OR RESPIRATION: DYSPNEA

BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY)

BEHAVIORAL: ATAXIA
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.
mouse LD50 intraperitoneal 190mg/kg (190mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1953, 1980.
mouse LD50 intravenous 39800ug/kg (39.8mg/kg) BEHAVIORAL: COMA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.
mouse LD50 oral 740mg/kg (740mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1953, 1980.
mouse LD50 subcutaneous 473mg/kg (473mg/kg)   Gekkan Yakuji. Pharmaceuticals Monthly. Vol. 22, Pg. 1953, 1980.
rabbit LDLo oral 250mg/kg (250mg/kg) BEHAVIORAL: ATAXIA

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

LUNGS, THORAX, OR RESPIRATION: DYSPNEA
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.
rat LD50 intravenous 44600ug/kg (44.6mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD

KIDNEY, URETER, AND BLADDER: HEMATURIA
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.
rat LD50 oral 1320mg/kg (1320mg/kg) KIDNEY, URETER, AND BLADDER: HEMATURIA

LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.
rat LD50 subcutaneous 3350mg/kg (3350mg/kg) LUNGS, THORAX, OR RESPIRATION: OTHER CHANGES

SKIN AND APPENDAGES (SKIN): "DERMATITIS, OTHER: AFTER SYSTEMIC EXPOSURE"

BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD
Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 1772, 1970.