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Substance Name: Buparlisib hydrochloride [USAN]
RN: 1312445-63-8
UNII: 194LK4P5K1
InChIKey: DGPLYAXBXJXEID-UHFFFAOYSA-N

Note

  • A pan class I PI3 kinase inhibitor with antineoplastic activity.

Classification Code

  • Antineoplastic

Molecular Formula

  • C18-H21-F3-N6-O2.Cl-H

Molecular Weight

  • 446.8588
 
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Names and Synonyms

Name of Substance

  • Buparlisib hydrochloride [USAN]

Synonyms

  • 5-(2,6-Bis(morpholin-4-yl)pyrimidin-4-yl)-4-(trifluoromethyl)pyridin-2-amine monohydrochloride
  • BKM120-AAA
  • Buparlisib hydrochloride
  • UNII-194LK4P5K1

Systematic Name

  • 2-Pyridinamine, 5-(2,6-di-4-morpholinyl-4-pyrimidinyl)-4-(trifluoromethyl)-, hydrochloride (1:1)

Registry Numbers

CAS Registry Number

  • 1312445-63-8

FDA UNII

  • 194LK4P5K1

System Generated Number

  • 1312445638

Structure Descriptors

InChI

1S/C18H21F3N6O2.ClH/c19-18(20,21)13-9-15(22)23-11-12(13)14-10-16(26-1-5-28-6-2-26)25-17(24-14)27-3-7-29-8-4-27;/h9-11H,1-8H2,(H2,22,23);1H

InChIKey

DGPLYAXBXJXEID-UHFFFAOYSA-N

Smiles

c1c(c(cnc1N)c2cc(nc(n2)N3CCOCC3)N4CCOCC4)C(F)(F)F.Cl